Qualitative study on barriers and facilitators to genetic testing in Hispanic patients with prostate cancer

BACKGROUND: Despite the importance of germline genetic evaluation in prostate cancer (PCa), fewer U.S. Hispanic patients receive it. METHODS: We conducted semi-structured in-depth interviews with U.S. Hispanic patients with PCa in English or Spanish on facilitators and barriers to germline genetic testing. RESULTS: Barriers and facilitators were multidimensional. Key facilitators include family benefit, actionability, trust in clinicians, bilingual educational materials and insurance coverage; whereas key barriers include confusion with other tests, fear of negative implications, low awareness and limited clinician-led counseling. CONCLUSIONS: Bilingual informational materials, public messaging, and greater clinician education are needed to promote equity in PCa genetic evaluation.

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Publication Details

Journal
Prostate Cancer and Prostatic Diseases
Published
2026-10-17
DOI
https://doi.org/10.1038/s41391-026-01166-9
Primary Topic
BRCA gene mutations in cancer
Type
article
Field-Weighted Citation Impact
0.00

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Qualitative study on barriers and facilitators to genetic testing in Hispanic patients with prostate cancer

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Prostate Cancer and Prostatic Diseases
BRCA gene mutations in cancer
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Qualitative study on barriers and facilitators to genetic testing in Hispanic patients with prostate cancer

Stacy Loeb, Susan Thomas Vadaparampil, Nataliya K. Byrne, Veda N. Giri, Tatiana Sanchez Nolasco, Mariana Rangel Camacho, Perla Chebli
article en

Abstract

BACKGROUND: Despite the importance of germline genetic evaluation in prostate cancer (PCa), fewer U.S. Hispanic patients receive it. METHODS: We conducted semi-structured in-depth interviews with U.S. Hispanic patients with PCa in English or Spanish on facilitators and barriers to germline genetic testing. RESULTS: Barriers and facilitators were multidimensional. Key facilitators include family benefit, actionability, trust in clinicians, bilingual educational materials and insurance coverage; whereas key barriers include confusion with other tests, fear of negative implications, low awareness and limited clinician-led counseling. CONCLUSIONS: Bilingual informational materials, public messaging, and greater clinician education are needed to promote equity in PCa genetic evaluation.

Prostate Cancer and Prostatic Diseases
Yale Cancer Center (US), Moffitt Cancer Center (US), New York University (US)
U.S. Department of Defense
Good health and well-being
Openalex Percentile: Top 15%
BRCA gene mutations in cancer
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