Association of physical activity with all-cause, cardiovascular, and cancer mortality among adults with diabetes: Mexico City Prospective Study
This study examined the association between physical activity (PA) and all-cause, cardiovascular, and cancer mortality among adults with diabetes. A total of 28,573 individuals aged ≥ 35 years from the Mexico City Prospective Study were included. PA was self-reported and categorized by frequency (< 1, 1–2, or ≥ 3 times/week), duration (< 30, 30–60, or > 60 min/session), and volume (combination of frequency and duration). Mean follow-up was 15.2 ± 5.7 years. For all-cause mortality, high PA frequency was associated with lower risk compared with low frequency (HR: 0.89; 95% CI: 0.84–0.94). High PA duration and volume were also associated with lower risk compared with low (HR: 0.83; 95% CI: 0.76–0.91 and HR: 0.85; 95% CI: 0.80–0.91, respectively); high volume was also associated with lower risk compared with medium volume (HR: 0.89; 95% CI: 0.81–0.98). For cardiovascular mortality, high PA frequency, duration and volume were associated with lower risk compared with low levels (HR: 0.89; 95% CI: 0.81–0.99; HR: 0.83; 95% CI: 0.71–0.97; and HR: 0.82; 95% CI: 0.73–0.92, respectively). PA was not associated with cancer mortality.
Authors
- Miguel Peralta (ORCID: https://orcid.org/0000-0001-6072-6012)
- Guillermo Daniel Felipe Barahona-Fuentes (ORCID: https://orcid.org/0000-0003-4913-9321)
- Bianca de Almeida-Pititto (ORCID: https://orcid.org/0000-0002-5907-5459)
- Eduardo Rossato de Victo (ORCID: https://orcid.org/0000-0002-4409-741X)
- Weder Alves da Silva (ORCID: https://orcid.org/0000-0002-7677-4710)
- Diego Giulliano Destro Christófaro (ORCID: https://orcid.org/0000-0001-9917-9992)
- Jacqueline Wahrhaftig (ORCID: https://orcid.org/0009-0003-5361-4014)
- Leandro F. M. Rezende (ORCID: https://orcid.org/0000-0002-7469-1399)
- Adilson Marques
- Yafeng Wang
- Gerson Ferrari
Institutions
- Universidad de Santiago de Chile (CL)
- Jiangnan University (CN)
- University of Lisbon (PT)
- Universidad Autónoma de Chile (CL)
- Universidade Estadual de Goiás (BR)
- Viña del Mar University (CL)
- Centro Interdisciplinar de Estudo da Performance Humana (PT)
- Universidade Estadual Paulista (Unesp) (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-10-16
- DOI
- https://doi.org/10.1038/s41598-026-76026-6
- Primary Topic
- Physical Activity and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Oxford
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Medical Research Council