Oxidized Xylan‐Based Multifunctional Composite Films for Photothermal Antibacterial and ROS ‐Scavenging Wound Dressings

ABSTRACT Wound management remains a global healthcare challenge, and the development of multifunctional dressings that integrate antibacterial and antioxidant properties is highly desirable. Herein, we report a composite film (OX/PDA‐MZC) composed of oxidized xylan (OX), polydopamine (PDA), and montmorillonite loaded with zinc oxide and cerium oxide (MZC). The film was fabricated via solution casting, and its physicochemical properties, biocompatibility, and wound‐healing efficacy were evaluated. The results showed that the OX/PDA‐MZC film exhibited excellent photothermal conversion performance, with a temperature rise to 92°C under 808 nm laser irradiation, and effective antibacterial activity against both Escherichia coli and Staphylococcus aureus . The composite film also demonstrated strong ROS‐scavenging capacity, reducing intracellular ROS levels by 60.5% and wound‐tissue ROS levels by 77.8%. In vivo experiments revealed that the OX/PDA‐MZC group achieved a 70.4% wound closure rate on Day 3 and promoted re‐epithelialization, collagen deposition, and angiogenesis while suppressing inflammation. These findings indicate that the OX/PDA‐MZC composite film holds great promise as an integrated wound dressing for effective tissue repair.