Synthesis, in silico study and cytotoxic evaluation of new benzimidazole derivatives as potential aromatase inhibitors
AIMS: ) was designed, synthesized, and evaluated as potential aromatase inhibitors with anticancer activity. MATERIALS AND METHODS: ADMET profiling were performed for the selected compounds. RESULTS: values (2.40-2.64 µM), surpassing cisplatin, while maintaining favorable selectivity profiles. CONCLUSIONS: as a promising lead for further development as a non-steroidal aromatase inhibitor for breast cancer therapy.
Authors
- Nour El-Huda Daoud (ORCID: https://orcid.org/0000-0003-1332-9609)
- Ebru Nur Ay (ORCID: https://orcid.org/0000-0001-7121-4362)
- Yusuf Özkay (ORCID: https://orcid.org/0000-0001-8815-153X)
- Gülşah Çongur (ORCID: https://orcid.org/0000-0002-0599-0993)
- Ulviye Acar Çevik (ORCID: https://orcid.org/0000-0003-1879-1034)
- Ayşen Işık (ORCID: https://orcid.org/0000-0002-1280-0019)
- Zafer Asım Kaplancıklı (ORCID: https://orcid.org/0000-0003-2252-0923)
- Kezban Uçar Çifci (ORCID: https://orcid.org/0000-0002-4758-4141)
- Yusuf Tutar (ORCID: https://orcid.org/0000-0003-2613-9644)
- Şennur Görgülü (ORCID: https://orcid.org/0000-0003-2026-2924)
- Emine Rana Bağcı (ORCID: https://orcid.org/0009-0004-7452-0532)
Institutions
- Al-Ahliyya Amman University (JO)
- Anadolu University (TR)
- Selçuk University (TR)
- Recep Tayyip Erdoğan University (TR)
- Bilecik Şeyh Edebali Üniversitesi (TR)
- Yozgat Bozok Üniversitesi (TR)
- Istinye University (TR)
- Afyonkarahisar Sağlık Bilimleri Üniversitesi
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2026-10-16
- DOI
- https://doi.org/10.1080/17568919.2026.2748643
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00