DOSE- AND TIME-DEPENDENT DIURETIC EFFECTS OF KHAMZAABAD MUMIJO IN DOGS

The present study investigated the diuretic effect of Khamzaabad Mumijo in conscious female dogs. The experiment was designed to evaluate the influence of different intravenous doses of Mumijo on urine output over a 4-hour observation period. Urine samples were collected hourly, with the initial collection serving as the control period. Mumijo was administered intravenously at doses of 1, 5, 10, 25, and 50 mg/kg in 10 mL of 0.9% physiological saline. The results demonstrated a marked increase in urine output following Mumijo administration compared with the vehicle control. The diuretic response generally increased with dose and was most prominent between 2 and 3 hours after administration. The highest urine output was observed with 10 mg/kg at 3 hours (268.0 ± 6.4), while substantial responses were also recorded at 25 and 50 mg/kg. These findings indicate that Khamzaabad Mumijo possesses pronounced diuretic activity following intravenous administration. Further studies are required to clarify the underlying renal mechanisms and establish its optimal dose and safety.