PuraStat as an Adjunct in the Management of Acute Gastric Variceal Haemorrhage: A Case Report

Acute variceal haemorrhage is a life-threatening complication of portal hypertension.Standard management includes haemodynamic resuscitation, vasoactive therapy, antibiotic prophylaxis, and urgent endoscopic haemostasis.We report a case in which PuraStat, a self-assembling peptide haemostatic gel, was used as an adjunct during active gastric variceal bleeding to provide temporary haemostatic control and improve endoscopic conditions for subsequent intervention.Following PuraStat application, haemostasis was achieved.This case supports a potential adjunctive role for PuraStat in selected patients with acute gastric variceal haemorrhage when immediate control proves difficult.PuraStat's temporary haemostatic effect may provide a bridge until more definitive management can be arranged in the correct setting.

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Publication Details

Journal
Cureus
Published
2026-10-15
DOI
https://doi.org/10.7759/cureus.117998
Primary Topic
Liver Disease and Transplantation
Type
article
Field-Weighted Citation Impact
0.00
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article

PuraStat as an Adjunct in the Management of Acute Gastric Variceal Haemorrhage: A Case Report

Ammar Al-Rifaie, Divine Stephen, Abhishek Mappilassery Ouseph
Cureus
Liver Disease and Transplantation
article

PuraStat as an Adjunct in the Management of Acute Gastric Variceal Haemorrhage: A Case Report

Ammar Al-Rifaie, Divine Stephen, Abhishek Mappilassery Ouseph
article en

Abstract

Acute variceal haemorrhage is a life-threatening complication of portal hypertension.Standard management includes haemodynamic resuscitation, vasoactive therapy, antibiotic prophylaxis, and urgent endoscopic haemostasis.We report a case in which PuraStat, a self-assembling peptide haemostatic gel, was used as an adjunct during active gastric variceal bleeding to provide temporary haemostatic control and improve endoscopic conditions for subsequent intervention.Following PuraStat application, haemostasis was achieved.This case supports a potential adjunctive role for PuraStat in selected patients with acute gastric variceal haemorrhage when immediate control proves difficult.PuraStat's temporary haemostatic effect may provide a bridge until more definitive management can be arranged in the correct setting.

Cureus
Chesterfield Royal Hospital (GB)
Openalex Percentile: Top 14%
Liver Disease and Transplantation
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