MnBn(CO)5-Catalyzed Cascade C–H Activation/Annulation to Construct Bridged N -Heterocycles
Abstract Herein, a manganese-catalyzed synthesis of bridged heterocycles via a C–H activation/annulation cascade between azomethine imines and Morita–Baylis–Hillman adducts is described. MnBn(CO)5 serves as a highly active catalyst, exhibiting unique and remarkable capability in C–H activation for this transformation. The reaction demonstrates broad substrate scope and good functional group tolerance, providing direct access to bridged pyrazolone frameworks under operationally simple and solvent-free conditions.
Authors
- Zhiting Wang (ORCID: https://orcid.org/0000-0001-9239-442X)
- Lutz Ackermann (ORCID: https://orcid.org/0000-0001-7034-8772)
- Nikolaos Kaplaneris (ORCID: https://orcid.org/0000-0002-7559-3088)
- Dexiang Feng (ORCID: https://orcid.org/0000-0003-0134-473X)
- Hui Wang (ORCID: https://orcid.org/0000-0002-0249-0432)
- Yang Sun (ORCID: https://orcid.org/0009-0004-9501-3599)
- Zhijun Feng
- Mengjiao Jiang
- Tiannan Wang
Institutions
- Anhui Normal University (CN)
- University of Göttingen (DE)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-10-16
- DOI
- https://doi.org/10.1021/acs.orglett.6c04098
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- National Natural Science Foundation of China
- Wannan Medical College
- Scientific Research Foundation of Education Department of Anhui Province of China
- European Research Council