Visual Loss in Syndromic Craniosynostosis with Neuro- Ophthalmological Manifestation in Crouzon Syndrome

Introduction: Crouzon syndrome is an autosomal dominant disorder with complete penetrance and variable expressivity caused by mutation in the fibroblast growth factor receptor 2 (FGFR2) gene. This disease is characterized by premature synostosis of coronal and sagittal sutures which begins in the first year of life. Purpose: To report two cases of Cruozon Syndrome. Method: This observational case report included two cases of cruozon syndrome presented at Ispahani Islamia Eye Institute and Hospital in January 2023. In case 1, VA was FF in both eyes. In case 2, VA 3/60 in right eye and 6/18 in left eye. On examination of case 1 & case 2, short anterior posterior diameter of the skull, wide orbital sepration, hypertelorism, lagopthalmus and V pattern XT, bilateral papilloedema with proptosis was found . All patients were treated conservatively with artificial tears, antibiotic eye ointment, eye taping at night. Consultations with the Oculoplasty, Cornea, Neuro-ophthalmology, Neuro- Surgery departments were performed. Conclusion: Early detection may help decrease the visual morbidity in affected individuals. J.Natl.Inst.Ophthalmol.2025;8(1): 75-78