Cumulative lifecourse cardiovascular health and interstitial lung abnormalities
Extract There are shared antecedent risk factors [1, 2] and pathobiological mechanisms [3] between pulmonary fibrosis and cardiovascular disease, suggesting these two distinct disease entities may be linked though common biological pathways. Studies consistently demonstrate a higher prevalence of cardiovascular disease among individuals with interstitial lung disease (ILD) [4]; however, these studies largely capture cardiovascular status at a single point, after pulmonary fibrosis has developed. This cross-sectional approach limits insight into whether cardiovascular health (CVH) truly represents an upstream risk factor for the development and progression of ILD.
Authors
- Raúl San Jośe Estépar (ORCID: https://orcid.org/0000-0002-3677-1996)
- Kavitha C. Selvan (ORCID: https://orcid.org/0000-0002-0988-0222)
- Gary Matthew Hunninghake (ORCID: https://orcid.org/0000-0001-9782-2841)
- Laura Anne Colangelo (ORCID: https://orcid.org/0000-0001-9322-705X)
- Rachel K. Putman (ORCID: https://orcid.org/0000-0002-8027-7450)
- Ravi Kalhan (ORCID: https://orcid.org/0000-0003-2443-0876)
- Anthony Joseph Esposito (ORCID: https://orcid.org/0000-0002-8636-0845)
- Kevin M. Grudzinski (ORCID: https://orcid.org/0000-0002-2317-5968)
- Bharat Thyagarajan (ORCID: https://orcid.org/0000-0001-6968-6985)
- George R. Washko (ORCID: https://orcid.org/0009-0004-1906-3244)
- Gabrielle Y. Liu (ORCID: https://orcid.org/0000-0003-2049-4231)
- B. Bemiss (ORCID: https://orcid.org/0000-0003-2877-4174)
- Elsie Bunyan
- Sadiya S. Khan
Institutions
- Northwestern University (US)
- Brigham and Women's Hospital (US)
- University of Minnesota (US)
- Brown University (US)
- University of California System (US)
- Northwestern University (PH)
- Northwestern Medicine (US)
- University of California Davis Medical Center (US)
- UC Davis Health (US)
- University of California, Davis (US)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2026-10-15
- DOI
- https://doi.org/10.1183/13993003.01207-2026
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute