Refining risk prediction in geriatric heart failure: the emergency heart failure mortality risk grade‑BI model under scrutiny

Risk stratification is critical for managing acute heart failure in older adults, yet existing tools often underperform in geriatric populations. Özdemir recently introduced the EHMRG‑BI model, integrating brain natriuretic peptide and endotracheal intubation with the Emergency Heart Failure Mortality Risk Grade score to improve 30‑day mortality prediction. While the model demonstrates improved discrimination in a single‑center derivation cohort, several methodological considerations warrant attention. The inclusion of intubation, a treatment decision rather than a baseline characteristic, may introduce bias and limit its utility as an arrival‑time tool. The absence of key geriatric domains such as frailty, functional status, and cognitive impairment may result in residual confounding. Additionally, modelling BNP as a linear predictor disregards its well‑documented non‑linear association with mortality. This Matters Arising offers a perspective on these challenges and proposes refinements, including external validation, integration of geriatric assessments, and flexible BNP modelling, to strengthen the model's clinical applicability.

Authors

Institutions

Publication Details

Journal
Aging Clinical and Experimental Research
Published
2026-10-15
DOI
https://doi.org/10.1007/s40520-026-03537-7
Primary Topic
Heart Failure Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Refining risk prediction in geriatric heart failure: the emergency heart failure mortality risk grade‑BI model under scrutiny

Xamida Juraqobilova, Kholmurod Qayumov, Sherzod Niyazov, Durdona Alimova et al.
Aging Clinical and Experimental Research
Heart Failure Treatment and Management
article

Refining risk prediction in geriatric heart failure: the emergency heart failure mortality risk grade‑BI model under scrutiny

Xamida Juraqobilova, Kholmurod Qayumov, Sherzod Niyazov, Durdona Alimova, Parvina Gaffarova, Kianoush A. h. Saberi L., Zaynura Kadirova
article en

Abstract

Risk stratification is critical for managing acute heart failure in older adults, yet existing tools often underperform in geriatric populations. Özdemir recently introduced the EHMRG‑BI model, integrating brain natriuretic peptide and endotracheal intubation with the Emergency Heart Failure Mortality Risk Grade score to improve 30‑day mortality prediction. While the model demonstrates improved discrimination in a single‑center derivation cohort, several methodological considerations warrant attention. The inclusion of intubation, a treatment decision rather than a baseline characteristic, may introduce bias and limit its utility as an arrival‑time tool. The absence of key geriatric domains such as frailty, functional status, and cognitive impairment may result in residual confounding. Additionally, modelling BNP as a linear predictor disregards its well‑documented non‑linear association with mortality. This Matters Arising offers a perspective on these challenges and proposes refinements, including external validation, integration of geriatric assessments, and flexible BNP modelling, to strengthen the model's clinical applicability.

Aging Clinical and Experimental ResearchVol. 38(1)
Andijan State University (UZ), Arak University of Medical Sciences (IR), Namangan State University (UZ), Bukhara State Medical Institute named after Abu Ali ibn Sino (UZ), Samarkand State Medical Institute (UZ), Termez State University (UZ), Tashkent State Medical University (UZ)
Good health and well-being
Openalex Percentile: Top 12%
Heart Failure Treatment and Management
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.