TORCH, not familial factors, increases likelihood of intellectual disability and autism

Congenital TORCH infections are known to injure the fetus, but little is known about their contribution to neurodevelopmental outcomes. A new study has found that congenital TORCH infections were associated with seven times the risk of intellectual disability and more than three times the risk of autism. In sibling comparisons (which allow researchers to see if living in the same family contributed to an outcome), the hazard ratio for intellectual disability was much higher: 11.28 — the intellectual disability was from the TORCH infection, not from the family environment or genes.

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Publication Details

Journal
The Brown University Child & Adolescent Psychopharmacology Update
Published
2026-10-15
DOI
https://doi.org/10.1002/cpu.31099
Primary Topic
Down syndrome and intellectual disability research
Type
article
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article

TORCH, not familial factors, increases likelihood of intellectual disability and autism

Alison Knopf
The Brown University Child & Adolescent Psychopharmacology Update
Down syndrome and intellectual disability research
article

TORCH, not familial factors, increases likelihood of intellectual disability and autism

Alison Knopf
article en

Abstract

Congenital TORCH infections are known to injure the fetus, but little is known about their contribution to neurodevelopmental outcomes. A new study has found that congenital TORCH infections were associated with seven times the risk of intellectual disability and more than three times the risk of autism. In sibling comparisons (which allow researchers to see if living in the same family contributed to an outcome), the hazard ratio for intellectual disability was much higher: 11.28 — the intellectual disability was from the TORCH infection, not from the family environment or genes.

The Brown University Child & Adolescent Psychopharmacology UpdateVol. 28(11)
Good health and well-being
Openalex Percentile: Top 10%
Down syndrome and intellectual disability research
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