Starting PFEP Rationally: Platform Architecture, Fraction Properties, Critical State Variables, and Decision Rules for Peptide Synthesis

Abstract. Paired-fraction electrochemical programming (PFEP) is presented as a five-module, experimentally testable process architecture in which complementary anodic and cathodic liquids are generated outside a peptide reactor, analytically qualified, represented as time-dependent chemical state vectors, and metered into an electrode-free synthesis or maturation step. The paper defines platform architecture, transferable fraction properties, critical state variables, route-entry rules, capacity-normalized dosing, state-age kinetics, minimum causal controls, stop rules, scale-up invariants, negative-use criteria, and reporting requirements for peptide-process studies. Evidence boundary. This is a perspective and methodological framework, not a report of a new laboratory experiment. Published electrochemistry, peptide chemistry, enzymology, folding, and pharmaceutical-development studies support individual premises but do not yet establish that ex situ paired electrochemical fractions improve a peptide process. Worked numerical examples are hypothetical design calculations. No clinical benefit, injectable-product safety, GMP readiness, regulatory acceptance, experimental yield, purity, potency, or shelf life is claimed. The deposited manuscript contains an English title and abstract together with a Russian title, author name, abstract, and keywords for bilingual indexing.