NOSE-OE: A molecular signaling map of the olfactory epithelium
The olfactory epithelium (OE) is a dynamic and complex sensory tissue in which continuous regeneration, neuronal differentiation, and tissue maintenance depend on coordinated molecular and cellular signaling. We developed NOSE-OE (Network of Signaling Events in the Olfactory Epithelium), an open-access knowledge resource that integrates mechanistic evidence from more than 300 publications into a standardized, computer-readable signaling network. NOSE-OE comprises over 500 molecular elements and 1,000 curated interactions and is implemented within the MINERVA platform for interactive exploration and network analysis. By connecting fragmented experimental evidence within a unified molecular framework, NOSE-OE enables the systematic investigation of signaling processes governing OE homeostasis and responses to perturbation. The resource provides a foundation for hypothesis generation and systems-level investigation of olfactory epithelial biology across physiological and disease contexts.
Authors
- Krishna Pal Singh (ORCID: https://orcid.org/0009-0004-8789-615X)
- Alessandro Nicoli (ORCID: https://orcid.org/0000-0001-6177-9749)
- Małgorzata M. Kogut (ORCID: https://orcid.org/0000-0003-4917-2674)
- Olaf Wolkenhauer A (ORCID: https://orcid.org/0000-0001-6105-2937)
- Shailendra K. Gupta (ORCID: https://orcid.org/0000-0002-3470-3260)
- Suchi Smita Gupta (ORCID: https://orcid.org/0000-0001-7663-0007)
- Antonella Di Pizio (ORCID: https://orcid.org/0000-0002-8520-5165)
- Francesco Ferri (ORCID: https://orcid.org/0009-0005-1824-0234)
- Federica Genovese (ORCID: https://orcid.org/0000-0003-3762-4776)
- Matti van Welzen
- Dominique Fastus (ORCID: https://orcid.org/0009-0006-6580-7261)
Institutions
- University of Geneva (CH)
- University of Copenhagen (DK)
- Center for Integrated Protein Science Munich (DE)
- Université Paris Cité (FR)
- Monell Chemical Senses Center (US)
- Universitätsmedizin Rostock (DE)
- Unit of Functional and Adaptive Biology (FR)
- Leibniz-Institute for Food Systems Biology at the Technical University of Munich (DE)
- University of Rostock (DE)
- Technical University of Munich (DE)
Publication Details
- Journal
- iScience
- Published
- 2026-10-15
- DOI
- https://doi.org/10.1016/j.isci.2026.117818
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00