Emergence of inactivating NOTCH1 mutations in an IDH-mutant astrocytoma with clinical resistance to vorasidenib treatment
Tomoyuki Nakano, Nicholas A Jessop, Charlotte I Wang, Maria Martinez-Lage, Itay Tirosh, Mario L Suva, Hiroaki Wakimoto, Daniel P Cahill, Christine Lu-Emers
Authors
- Itay Tirosh (ORCID: https://orcid.org/0000-0001-5477-2987)
- Hiroaki Wakimoto (ORCID: https://orcid.org/0000-0001-8225-241X)
- Mario L. Suvà (ORCID: https://orcid.org/0000-0001-9898-5351)
- Julie J. Miller (ORCID: https://orcid.org/0000-0002-1288-593X)
- Daniel P. Cahill (ORCID: https://orcid.org/0000-0003-2552-6546)
- Nicholas A. Jessop
- Christine Lu‐Emerson (ORCID: https://orcid.org/0000-0002-6817-6657)
- María Martínez-Lage (ORCID: https://orcid.org/0000-0002-5859-7562)
- Tomoyuki Nakano (ORCID: https://orcid.org/0000-0003-0933-1714)
- Charlotte I Wang
Institutions
- Broad Institute (US)
- Maine Medical Center (US)
- Massachusetts General Hospital (US)
- New England Cancer Specialists (US)
- American Committee for the Weizmann Institute of Science (US)
- Center for Neuro-Oncology (US)
- MaineHealth (US)
- Center for Cancer Research (US)
- Institute of Science Tokyo (JP)
- Weizmann Institute of Science (IL)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2026-10-15
- DOI
- https://doi.org/10.1093/neuonc/noag174
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00