Pan-genomics in One Health: linking pathogens, hosts, and environments

The One Health approach recognizes the interdependence of human, animal, and environmental health for managing global health challenges. The increasing incidence of zoonotic diseases, antimicrobial resistance, and environmental degradation underscores the relevance of integrated surveillance strategies. In this context, pan-genomics has emerged as a valuable tool for characterizing the genetic diversity of bacterial pathogens across hosts, geographic regions, and ecological niches. By distinguishing core from accessory genome components, pan-genomic analyses inform vaccine target identification through reverse vaccinology; elucidate antimicrobial resistance determinants; and reveal host adaptation mechanisms. This review examines the application of pan-genomics within the One Health framework, focusing on bacterial pathogens of relevance to human, animal, and environmental health, including Bacillus anthracis , Mycobacterium bovis , Corynebacterium pseudotuberculosis , Mycobacterium marinum , Leptospira interrogans , Yersinia pestis , Francisella tularensis , Corynebacterium ulcerans , and Vibrio vulnificus . For each pathogen, we discuss available genomic data, pan-genome characteristics, and implications for surveillance, diagnostics, and intervention strategies. Additionally, we address the role of metagenomics in environmental monitoring and the contribution of computational approaches, such as reverse vaccinology and subtractive genomics, to the development of novel therapeutic and prophylactic targets.

Authors

Institutions

Publication Details

Journal
Academia molecular biology and genomics.
Published
2026-10-15
DOI
https://doi.org/10.20935/acadmolbiogen8585
Primary Topic
Zoonotic diseases and public health
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Pan-genomics in One Health: linking pathogens, hosts, and environments

Pedro Henrique Marques, Flávia Figueira Aburjaile, Victor Augusto Sallum Ceballos, Fabiana Vieira Dominici et al.
Academia molecular biology and genomics.
Zoonotic diseases and public health
article

Pan-genomics in One Health: linking pathogens, hosts, and environments

Pedro Henrique Marques, Flávia Figueira Aburjaile, Victor Augusto Sallum Ceballos, Fabiana Vieira Dominici, Arun Kumar Jaiswal, Siomar de Castro Soares, Franciele Maboni Siqueira, Andrei Giacchetto Felice, Sheila da Silva, Aristoteles Goes Neto, Diego Lucas Neres Rodrigues, Wylerson Guimarães Nogueira, Rodrigo Bentes Kato, Roberta Torres Chideroli, Ulisses de Pádua Pereira, Rommel Thiago Jucá Ramos, Roberto Montes de Oca Jiménez, Vasco Azevedo, Thais Vilela Rodrigues, Mateus Matiuzzi da Costa, Rodrigo Dias Oliveira Carvalho, Eduarda Sousa Guimarães, Sandeep Tiwari, Selma Soares de Oliveira
article en

Abstract

The One Health approach recognizes the interdependence of human, animal, and environmental health for managing global health challenges. The increasing incidence of zoonotic diseases, antimicrobial resistance, and environmental degradation underscores the relevance of integrated surveillance strategies. In this context, pan-genomics has emerged as a valuable tool for characterizing the genetic diversity of bacterial pathogens across hosts, geographic regions, and ecological niches. By distinguishing core from accessory genome components, pan-genomic analyses inform vaccine target identification through reverse vaccinology; elucidate antimicrobial resistance determinants; and reveal host adaptation mechanisms. This review examines the application of pan-genomics within the One Health framework, focusing on bacterial pathogens of relevance to human, animal, and environmental health, including Bacillus anthracis , Mycobacterium bovis , Corynebacterium pseudotuberculosis , Mycobacterium marinum , Leptospira interrogans , Yersinia pestis , Francisella tularensis , Corynebacterium ulcerans , and Vibrio vulnificus . For each pathogen, we discuss available genomic data, pan-genome characteristics, and implications for surveillance, diagnostics, and intervention strategies. Additionally, we address the role of metagenomics in environmental monitoring and the contribution of computational approaches, such as reverse vaccinology and subtractive genomics, to the development of novel therapeutic and prophylactic targets.

Academia molecular biology and genomics.Vol. 3(4)
Universidade Federal de Minas Gerais (BR), Universidade Federal do Rio de Janeiro (BR), Universidade Federal da Bahia (BR), Universidade Estadual de Londrina (BR), Universidade Federal do Rio Grande do Sul (BR), Universidade de Ribeirão Preto (BR), Universidad Autónoma del Estado de México (MX), Universidade de São Paulo (BR), Universidade Federal de Alfenas (BR), Microbiologie de l’alimentation au service de la santé (FR), Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR), Universidade Federal do Triângulo Mineiro (BR), Institut Pasteur de São Paulo (BR), Universidade Federal do Vale do São Francisco (BR), Universidade Federal do Pará (BR), King Abdullah University of Science and Technology (SA)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico
Good health and well-being
Openalex Percentile: Top 11%
Zoonotic diseases and public health
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.