Clinicopathologic characteristics and molecular landscape for pseudomyxoma peritonei of appendiceal origin

Appendectomy as the standard treatment for acute appendicitis has been challenged by accumulating evidence supporting nonoperative management with antibiotics as a potential primary treatment.This review aimed to summarize the clinical outcomes and the optimal indications for nonoperative management of acute appendicitis in adults.Current evidence suggests that uncomplicated and complicated appendicitis have different pathophysiologies and should be treated differently.Nonoperative management for uncomplicated appendicitis was not inferior to appendectomy in terms of complications and length of stay, with less than a 30% failure rate at 1 year.The risk of perforation and postoperative complications did not increase even if nonoperative management failed.Complicated appendicitis with localized abscess or phlegmon could also be treated conservatively, with a success rate of more than 80%.An interval appendectomy following successful nonoperative management is recommended only for patients over the age of 40 years to exclude appendiceal malignancy.The presence of appendicoliths increased the risk of treatment failure and complications; thus, it may be an indication for appendectomy.Nonoperative management is a safe and feasible option for both uncomplicated and complicated appendicitis.Patients should be informed that nonoperative management may be a safe alternative to surgery, with the possibility of treatment failure.