Laboratory-to-Industrial Translation in Plant-Derived Bioproduct Valorization: A Critical Integrative Review and Proposed Framework for Route-Level Evidence Assessment

Gross extraction yield alone cannot establish product conformity or broader economic and environmental performance. This critical integrative review examines evidence linking laboratory findings to industrially relevant claims for plant-derived bioproduct valorization. It synthesizes seven evidence streams and proposes specification-adjusted route accounting, connecting route identity, output states, and claim-specific requirements. Selected elements were illustrated retrospectively using 17 purposively selected evidence packages. Artemisinin retention decreased from 90.0% after maceration to 37.3% after crystallization on the same initial artemisinin basis. Higher grapefruit-pectin yield accompanied changes in product properties without establishing functional equivalence. Red-grape-pomace economic preference depended on price assumptions. For microencapsulated pomegranate-peel extract powder, the highest deterministic net present value and highest probability of a positive net present value occurred in different modeled scale scenarios. Its separately scoped life cycle assessment identified freeze-drying as a hotspot without establishing comparative environmental improvement. No selected package provided verifiable observed-displacement evidence at the documented access level. The framework distinguishes supported conclusions from unresolved requirements; the cases illustrate its logic rather than validate its performance. Purposive selection, limited source access, and single-author assessment constrain interpretation. Independent and prospective evaluation is needed before reproducibility or decision benefits can be established.