Early measurement of ST2 and REG3α has a prognostic impact in haploidentical transplantation with post-transplant cyclophosphamide
Research on predictive biomarkers in haploidentical SCT (haplo-HSCT) with post-transplant cyclophosphamide (PTCy) remains limited, particularly regarding the critical first week post-infusion. We prospectively evaluated serum ST2, REG3α, and the MAGIC algorithm pre-conditioning and at days 0, +7, +14, and +21 in 81 adult patients undergoing haplo-HSCT with PTCy. ST2 and REG3α surged significantly from pre-conditioning to day 0 (p=0.031 and p.
Authors
- Maria Luisa Martín-Mateos
- Rebeca Maldonado
- Olga López‐Villar
- Sara Marcos
- Almudena Cabero (ORCID: https://orcid.org/0000-0002-8312-9891)
- Lourdes Vázquez (ORCID: https://orcid.org/0000-0001-8191-0046)
- Miguel Alcoceba (ORCID: https://orcid.org/0000-0002-3819-4846)
- Rodrigo Gil-Manso (ORCID: https://orcid.org/0000-0003-2093-7119)
- Miriam López-Parra (ORCID: https://orcid.org/0000-0002-2949-0627)
- Lucía López‐Corral (ORCID: https://orcid.org/0000-0003-1908-5596)
- Marta Fonseca Santos (ORCID: https://orcid.org/0000-0002-9641-1730)
- Ramón García‐Sánz (ORCID: https://orcid.org/0000-0003-4120-2787)
- Fermin M. Sanchez-Guijo (ORCID: https://orcid.org/0000-0002-7076-7739)
- Ana García‐Bacelar
- Francisco Javier Gil‐Etayo (ORCID: https://orcid.org/0000-0002-6152-0080)
- Inmaculada Sánchez-Villares
- María García‐Álvarez (ORCID: https://orcid.org/0000-0001-8864-1168)
- Ana África Martín
- Estefanía Pérez
- Alejandro Avendaño
- Luis Antonio Corchete Sanchez (ORCID: https://orcid.org/0000-0003-4577-8599)
- Luis A. Marín
- Ana Isabel Sánchez
- Mónica Cabrero
- Mónica Baile
Institutions
- Instituto de Investigación Biomédica de Salamanca (ES)
- Centro de Investigación del Cáncer (ES)
- Complejo Hospitalario Universitario de Albacete (ES)
Publication Details
- Journal
- Haematologica
- Published
- 2026-10-15
- DOI
- https://doi.org/10.3324/haematol.2026.300846
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00