Primary Conjunctival Melanoma of the Palpebral Conjunctiva: A Report of a Rare Case

Conjunctival melanoma (CoM) is a rare but aggressive type of malignant ocular tumor with a wide spectrum of possible clinical presentations.Palpebral conjunctival localization is associated with special difficulties, as lesions may be hidden from visualization during ophthalmological examination, and therefore, the diagnosis may be delayed.Treatment should include a number of methods and consist of a complex approach, with surgical excision being the key point.According to tumor extension and histology, other treatment options, such as cryotherapy, topical chemotherapy, radiotherapy, immunotherapy, and targeted therapy, may be used as well.Prognosis is determined by tumor characteristics, local extension, and the completeness of surgical excision.We report a case of a patient with primary melanoma of the palpebral conjunctiva, which is a rather unusual presentation and has presented certain diagnostic and therapeutic challenges.A thorough clinical and imaging study of the lesion and subsequent surgical treatment and postoperative follow-up have been carried out.The described case demonstrates the need for a careful clinical examination of the conjunctiva, the assessment of the tumor extent, surgical excision, and multidisciplinary treatment.Follow-up should be long-lasting and meticulous to detect local recurrence and disease progression.

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Journal
Cureus
Published
2026-10-15
DOI
https://doi.org/10.7759/cureus.117950
Primary Topic
Ocular Oncology and Treatments
Type
article
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article

Primary Conjunctival Melanoma of the Palpebral Conjunctiva: A Report of a Rare Case

Rhizlane Belbaraka, Othmane Zouiten, Leila Afani, Latifa Azarou et al.
Cureus
Ocular Oncology and Treatments
article

Primary Conjunctival Melanoma of the Palpebral Conjunctiva: A Report of a Rare Case

Rhizlane Belbaraka, Othmane Zouiten, Leila Afani, Latifa Azarou, Mohamed Elfadli
article en

Abstract

Conjunctival melanoma (CoM) is a rare but aggressive type of malignant ocular tumor with a wide spectrum of possible clinical presentations.Palpebral conjunctival localization is associated with special difficulties, as lesions may be hidden from visualization during ophthalmological examination, and therefore, the diagnosis may be delayed.Treatment should include a number of methods and consist of a complex approach, with surgical excision being the key point.According to tumor extension and histology, other treatment options, such as cryotherapy, topical chemotherapy, radiotherapy, immunotherapy, and targeted therapy, may be used as well.Prognosis is determined by tumor characteristics, local extension, and the completeness of surgical excision.We report a case of a patient with primary melanoma of the palpebral conjunctiva, which is a rather unusual presentation and has presented certain diagnostic and therapeutic challenges.A thorough clinical and imaging study of the lesion and subsequent surgical treatment and postoperative follow-up have been carried out.The described case demonstrates the need for a careful clinical examination of the conjunctiva, the assessment of the tumor extent, surgical excision, and multidisciplinary treatment.Follow-up should be long-lasting and meticulous to detect local recurrence and disease progression.

Cureus
Centre Hospitalier Universitaire Mohammed VI (MA), Sup de Co Marrakech (MA)
Good health and well-being
Openalex Percentile: Top 9%
Ocular Oncology and Treatments
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