Base-Promoted Hydrophosphorylation of Enaminones for the Synthesis of Geminal Phosphoryl Amino Ketones
The direct hydrophosphorylation reaction of NH-enaminones has been achieved by simple base promotion with diaryl phosphine oxides as reaction partners. The synthesis of divergent β-phosphoryl-β-amino ketones has been allowed under mild heating (30 °C) in a green medium of 2-methyl tetrahydrofuran (2-MeTHF) without employing any metal reagent.
Authors
- Jie‐Ping Wan (ORCID: https://orcid.org/0000-0002-9367-8384)
- Xi Li
- Gengxin Li
- Quanquan Zhou
Institutions
- Changsha Medical University (CN)
- Nanjing Forestry University (CN)
- Jiangxi Normal University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-10-15
- DOI
- https://doi.org/10.1021/acs.joc.6c01748
- Primary Topic
- Organophosphorus compounds synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province