Comparative Effectiveness of 0.2% and 0.3% Hyaluronic Acid Gels for the Treatment of Denture Stomatitis: A Prospective Randomized Clinical Trial

Background: Denture stomatitis is a common inflammatory condition among removable denture wearers, frequently associated with denture biofilm, microbial colonization and local mucosal irritation. Hyaluronic acid (HA) possesses moisturizing, anti-inflammatory and tissue-healing properties and may be beneficial in managing inflamed oral mucosa. Aim: To compare the clinical effectiveness of 0.2% and 0.3% HA gels in the management of denture stomatitis over a 7-day period. Materials and Methods: A prospective randomized comparative clinical study was conducted in patients clinically diagnosed with denture stomatitis. Participants were randomly allocated into two groups. Group A received 0.2% HA gel (Gengigel®, Ricerfarma), while Group B received 0.3% HA gel (Gingicare®, Oradox). Both gels were applied topically three times daily for 7 days. All participants received standardized instructions regarding denture hygiene, oral hygiene and overnight denture removal. Clinical severity and patient-reported symptoms were assessed at baseline, Day 3 and Day 7. Results: Both groups demonstrated considerable improvement in clinical signs and symptoms by Day 7. The 0.3% HA gel group showed a slightly greater overall clinical improvement than the 0.2% HA group, particularly in reduction of mucosal erythema and subjective discomfort. However, the difference between the two groups was relatively small. Conclusion: Both HA formulations were effective in the management of denture stomatitis within one week. Although the 0.3% HA gel demonstrated a slightly better clinical response, both formulations showed favorable therapeutic outcomes.