Topological Structure Regulation of NBGE ‐ b ‐ PG Copolymers for Modified Polyvinyl Chloride and Its Antifouling Property Study

ABSTRACT Nonspecific adsorption of biological foulants like proteins on medical material surfaces can trigger coagulation, infection and immune rejection, which greatly limit their practical applications. Physically blending amphiphilic copolymers with medical substrates has proven to be an effective way to solve these problems. Nevertheless, the modified medical materials still exhibit obvious deficiencies in antibiofouling adhesion capacity and long‐term service stability. Meanwhile, the structure‐performance relationship between copolymer architecture and antibiofouling behavior remains to be further elucidated. To address these issues, two amphiphilic copolymers with different topological structures were designed and synthesized, and physically blended with PVC matrix to prepare high‐performance and durable antifouling polymer films. In the prepared copolymers, polyglycidol ( PG ) serves as the hydrophilic segment to endow the films with favorable antibioadhesion capability, while poly( n ‐butyl glycidyl ether) ( NBGE ) acts as the hydrophobic segment to synergistically enhance the structural stability of copolymers. Experimental results reveal that the copolymers with hyperbranched hydrophilic segments ( HPG ) possess superior antibiofouling performance. Specifically, the adsorption capacity of bovine serum albumin is reduced by 92.3%, the adhesion amount of platelets is decreased by 96.0%, and a nearly complete bacterial inhibition effect is achieved. Furthermore, the blended films constructed by hyperbranched structured copolymers can maintain stable antibiofouling properties under stretching, friction and immersion conditions. This facile strategy provides a novel insight for the development of high‐performance antibiofouling PVC materials toward biomedical applications.