Restoration of frequency-dependent myocardial reserve after TAVI in severe aortic stenosis: an invasive hemodynamic study
This study provides direct invasive human evidence that frequency-dependent myocardial reserve is acutely restored after TAVI in severe aortic stenosis. Controlled atrial pacing revealed blunted force-frequency and relaxation-frequency responses before valve replacement, despite preserved ejection fraction, with rapid recovery after afterload relief. These findings show that impaired myocardial reserve in pressure-overload remodeling is functionally reversible and tightly linked to loading conditions.
Authors
- Dimitri Buytaert (ORCID: https://orcid.org/0000-0003-0592-5873)
- Ward Heggermont (ORCID: https://orcid.org/0000-0002-5368-2223)
- Sara Corradetti (ORCID: https://orcid.org/0000-0002-6588-4906)
- Nikolaos Stalikas (ORCID: https://orcid.org/0000-0002-0190-5392)
- Anthony Kechichian (ORCID: https://orcid.org/0000-0002-1551-4624)
- Raffaella Mistrulli (ORCID: https://orcid.org/0000-0001-7218-9891)
- Jeroen Dauw (ORCID: https://orcid.org/0000-0003-4605-3450)
- Tatyana Yevgenyevna Storozhenko (ORCID: https://orcid.org/0000-0002-9158-2012)
- Marc Vanderheyden (ORCID: https://orcid.org/0000-0003-3050-5221)
- Michele Mattia Viscusi (ORCID: https://orcid.org/0000-0002-5047-973X)
- Eric Wyffels (ORCID: https://orcid.org/0000-0002-9906-4682)
- Riet Dierckx
- Emiliano Fiori (ORCID: https://orcid.org/0000-0001-8749-8558)
- Jozef Bartunek
- Emanuele Barbato (ORCID: https://orcid.org/0000-0002-0050-5178)
Institutions
- L.T. Malaya National Therapy Institute of the National Academy of Medical Sciences of Ukraine (UA)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- American Journal of Physiology-Heart and Circulatory Physiology
- Published
- 2026-10-14
- DOI
- https://doi.org/10.1152/ajpheart.00441.2026
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Facoltà di Medicina e Psicologiaa, Sapienza Università di Roma
- Hellenic Society of Cardiology