Prescribed insulin use in type II diabetes mellitus and skin cancer risk: A systematic review 3
We conducted a systematic review of studies that have investigated the association between prescribed insulin for type 2 diabetes and the risk of skin cancer. Four studies met the inclusion criteria, one trial and three cohort studies. Of these, all bar one were high-quality. The majority of studies report no statistically significant association and the direction was inconsistent. Future research should evaluate the effect of different insulin analogues, dosages, and exposure periods, and consider confounding by indication.
Authors
- Girum T. Assefa (ORCID: https://orcid.org/0000-0001-9526-7899)
- Zenas Z N Yiu (ORCID: https://orcid.org/0000-0002-1831-074X)
- Lesley Elizabeth Rhodes (ORCID: https://orcid.org/0000-0002-9107-6654)
- Sonia Gran (ORCID: https://orcid.org/0000-0002-2443-5100)
- ISKANDAR RAUF IDRIS (ORCID: https://orcid.org/0000-0002-7548-8288)
- Lydia Tutt
- Grace Baby
- Zoe Claire Venables (ORCID: https://orcid.org/0000-0002-9929-2693)
- Adele Sotgiu
Institutions
- University of East Anglia (GB)
- University of Nottingham (GB)
- Hawassa University (ET)
- Norfolk and Norwich University Hospital (GB)
- Manchester Academic Health Science Centre (GB)
- University Hospitals of Leicester NHS Trust (GB)
- Salford Royal Hospital (GB)
- NIHR Manchester Biomedical Research Centre (GB)
- Northern Care Alliance NHS Foundation Trust (GB)
Publication Details
- Journal
- Clinical and Experimental Dermatology
- Published
- 2026-10-13
- DOI
- https://doi.org/10.1093/ced/llag444
- Primary Topic
- Skin Diseases and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00