Cellular diversity in neural organoids is critical for neurodegenerative disease modeling

Neuroinflammation and vascular dysfunction are hallmarks of most neurodegenerative diseases. For organoids intended to model neurodegeneration, immune, and vascular cells should therefore be considered fundamental components, rather than optional additions.

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Publication Details

Journal
PLoS Biology
Published
2026-10-14
DOI
https://doi.org/10.1371/journal.pbio.3004074
Primary Topic
Neurogenesis and neuroplasticity mechanisms
Type
article
Field-Weighted Citation Impact
0.00

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article

Cellular diversity in neural organoids is critical for neurodegenerative disease modeling

Shi‐Yan Ng, Shiying Liu
PLoS Biology
Neurogenesis and neuroplasticity mechanisms
article

Cellular diversity in neural organoids is critical for neurodegenerative disease modeling

Shi‐Yan Ng, Shiying Liu
article en

Abstract

Neuroinflammation and vascular dysfunction are hallmarks of most neurodegenerative diseases. For organoids intended to model neurodegeneration, immune, and vascular cells should therefore be considered fundamental components, rather than optional additions.

PLoS BiologyVol. 24(10)
Agency for Science, Technology and Research (SG)
National Research Foundation Singapore
Good health and well-being
Openalex Percentile: Top 15%
Neurogenesis and neuroplasticity mechanisms
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