A Rare Case of a Large Vulvovaginal Cellular Leiomyoma in a Young Female Patient: A Case Report

We present a rare clinical case of a 40-year-old woman with slowly growing vulvovaginal masses.According to the patient's history, the tumors had been gradually increasing in size over the past six years.Physical examination revealed two independent, well-circumscribed masses: a large mass in the left vulvar region and a medium-sized mass in the anterior vaginal wall.Magnetic resonance imaging (MRI) showed that both lesions were of soft tissue origin and did not invade adjacent organs.Histomorphological examination of the incisional biopsy revealed a benign mesenchymal neoplasia with signs of smooth muscle differentiation, increased cellularity, without cytological atypia, pronounced mitotic activity, and tumor necrosis.After radical surgical excision, the diagnosis of cellular leiomyoma was confirmed.Reconstructive surgery was performed to correct the defect resulting from the removal of the large vulvar mass.The postoperative period was uneventful, and the patient was discharged on the first day after surgery.This case highlights the diagnostic difficulty of rare vulvovaginal mesenchymal tumors and demonstrates the importance of a comprehensive clinical, radiological, and histopathological evaluation for accurate diagnosis and appropriate treatment.

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Publication Details

Journal
Cureus
Published
2026-10-14
DOI
https://doi.org/10.7759/cureus.117919
Primary Topic
Urologic and reproductive health conditions
Type
article
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article

A Rare Case of a Large Vulvovaginal Cellular Leiomyoma in a Young Female Patient: A Case Report

David Gagua, Nino Demetrashvili, Beka Metreveli, Elene Lipartia et al.
Cureus
Urologic and reproductive health conditions
article

A Rare Case of a Large Vulvovaginal Cellular Leiomyoma in a Young Female Patient: A Case Report

David Gagua, Nino Demetrashvili, Beka Metreveli, Elene Lipartia, Aleksandre Gvaladze, Tinatin Gagua, Tamaz Nikolaishvili
article en

Abstract

We present a rare clinical case of a 40-year-old woman with slowly growing vulvovaginal masses.According to the patient's history, the tumors had been gradually increasing in size over the past six years.Physical examination revealed two independent, well-circumscribed masses: a large mass in the left vulvar region and a medium-sized mass in the anterior vaginal wall.Magnetic resonance imaging (MRI) showed that both lesions were of soft tissue origin and did not invade adjacent organs.Histomorphological examination of the incisional biopsy revealed a benign mesenchymal neoplasia with signs of smooth muscle differentiation, increased cellularity, without cytological atypia, pronounced mitotic activity, and tumor necrosis.After radical surgical excision, the diagnosis of cellular leiomyoma was confirmed.Reconstructive surgery was performed to correct the defect resulting from the removal of the large vulvar mass.The postoperative period was uneventful, and the patient was discharged on the first day after surgery.This case highlights the diagnostic difficulty of rare vulvovaginal mesenchymal tumors and demonstrates the importance of a comprehensive clinical, radiological, and histopathological evaluation for accurate diagnosis and appropriate treatment.

Cureus
David Tvildiani Medical University (GE)
Good health and well-being
Openalex Percentile: Top 13%
Urologic and reproductive health conditions
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