Mapping the Knowledge Structure and Thematic Trends of Wilms Tumor: Insights From Text Mining

ABSTRACT Background Wilms tumor (WT), also known as nephroblastoma, is one of the most common renal malignancies in children. This study aimed to systematically characterize the knowledge structure, research evolution, and major research hotspots in WT. Methods Publications on WT from 1945 to 2024 were retrieved from the Web of Science Core Collection. GraphPad Prism and Microsoft Excel were used for data analysis. Co‐occurrence, collaboration network, co‐citation, and bibliographic coupling analyses were performed using VOSviewer and Bibliometrix. Results A total of 4695 WT‐related papers published from 1945 to 2024 were screened and analyzed. Annual publication output showed an overall upward trend, peaking in 2019. The United States and Harvard University were the most productive country and institution, respectively. The Journal of Pediatric Surgery published the highest number of WT‐related papers. “Biomarker,” “nephron‐sparing surgery,” and “immunotherapy” are likely to receive increasing attention and emerge as prominent research hotspots. Conclusions WT research encompasses various aspects of basic science and therapeutic management. Recent research hotspots include “biomarkers,” “nephron‐sparing surgery,” and “immunotherapy.” International collaboration and translational studies are essential to advancing research in this field.