Alkaline phosphatase levels and Parkinson’s disease genetic subtypes: a threshold effect

The association between Alkaline Phosphatase (ALP) levels and Parkinson’s Disease (PD) genetic subtypes, including sporadic and genetic forms, remains unclear. This study aimed to explore the association between ALP and PD subtypes using the PPMI database. We conducted a cross-sectional analysis of 1334 participants, divided into sporadic PD (1020 cases) and genetic PD (314 cases) groups. Multivariate logistic regression was used to assess the association between ALP levels and PD genetic subtypes, adjusting for potential confounders. The crude and adjusted odds ratios (ORs) for the association between ALP levels and genetic PD genetic subtypes were 1.1 (95% CI: 1.04–1.16) and 1.12 (95% CI: 1.05–1.18), respectively, indicating a positive association. A significant non-linear relationship was observed (Adjust P for non-linearity = 0.03), with a threshold effect at ALP levels ≥ 58.58 (OR = 1.202, 95% CI: 1.096–1.317, P = 0.002). Subgroup analyses and sensitivity analyses showed consistent results. Our findings demonstrate an association between ALP levels and PD genetic subtypes, with a significant threshold effect. Given the cross-sectional nature of this study, these results are hypothesis-generating and warrant further investigation. Future longitudinal and mechanistic studies are needed to validate this association and to explore its potential biological relevance.