Dehydrogenative Aminooxygenation of Cyclopropylamides Enabled by Cooperative Electrocatalysis

Abstract Herein, we report an unprecedented, sustainable, and atom-economic electrochemical [3 + 3] annulation of cyclopropylamides. Readily accessible amides, carbamates, and ureas serve as dual N/O-functional precursors to precisely steer reaction regiochemistry. This protocol allows straightforward assembly of structurally diversified 1,3-oxazines with exclusive regiocontrol under mild conditions. The developed strategy features excellent functional group tolerance, broad substrate scope, and good scalability at higher reaction concentrations and is also applicable to the late-stage modification of bioactive molecules. Mechanistic studies support a distinctive pathway mediated by synergistic ferrocene/iodide dual catalysis.