Fertility counseling and preservation considerations in patients with gynecologic and non‐gynecologic BRCA and Lynch‐associated malignancies
Lynch syndrome and BRCA-mutation associated malignancies are fortunately rare. Affected patients have an increased risk of cancer diagnosis at a young age, often significantly overlapping with their reproductive years. In helping these patients, oncologists must navigate the following areas of care: cancer prevention, impact of cancer prevention strategies on fertility, impact of cancer treatment on fertility, effective cancer therapies, and preservation of fertility without compromising oncologic outcomes. This intersectionality between fertility preservation and effective cancer prevention/therapy makes the care of these patients extremely complex. With the utility of multidisciplinary care models, careful employment of evolving new treatment strategies, it is possible for patients to achieve their fertility desires while at the same time being protected from the risks imposed by their genetic mutations.
Authors
- Neerja Bhatla
- Anna Weimer (ORCID: https://orcid.org/0000-0001-6417-1923)
- Angélica Fletcher
- Alexander Babatunde Olawaiye (ORCID: https://orcid.org/0000-0002-2833-9255)
- Hextan YS NGAN
- Sarikapan Wilailak (ORCID: https://orcid.org/0000-0001-7288-494X)
- René Pareja (ORCID: https://orcid.org/0000-0003-0093-0438)
- Christina Fotopoulou (ORCID: https://orcid.org/0009-0008-1672-2901)
- Nadeem R. Abu Rustum
- Ka Yu Tse (ORCID: https://orcid.org/0000-0001-8330-0970)
- David Mutch
- Mauricio Cuello
- Kenneth Ruzindana
- Eva Chalas
- Barbara Schmalfeldt
- Jalid Sehouli
- Nozomu Yanaihara
- Yana Zou
- Munanchiso Ndukwe Iheme
- Nicole Conchin
- Ting‐Chang Chang
Institutions
- Jikei University School of Medicine (JP)
- Memorial Sloan Kettering Cancer Center (US)
- Shenyang Agricultural University (CN)
- Long Island University (US)
- Pontificia Universidad Católica de Chile (CL)
- University of Pittsburgh (US)
- Chang Gung University (TW)
- Washington University in St. Louis (US)
- Mahidol University (TH)
- University of Rwanda (RW)
- MSB Medical School Berlin (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Instituto Nacional de Cancerología (CO)
- University Hospital Hradec Králové (CZ)
- Ramathibodi Hospital (TH)
- Imperial College London (GB)
- All India Institute of Medical Sciences (IN)
- Medical University of Vienna (AT)
- University of Hong Kong (HK)
Publication Details
- Journal
- International Journal of Gynecology & Obstetrics
- Published
- 2026-10-09
- DOI
- https://doi.org/10.1002/ijgo.71419
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00