Fibrinolytic Fury: Post-Traumatic Hyperfibrinolysis in a Patient with Severe Hemophilia A

Hyperfibrinolysis, although rare in hemophilia, can complicate trauma care by increasing bleeding and challenging hemostatic control. We report a case of a young male with severe congenital hemophilia A who sustained fractures of the left leg and right distal radius following trauma and subsequently developed laboratory-confirmed hyperfibrinolysis. Factor VIII replacement, along with tranexamic acid, resulted in successful hemostasis and enabled definitive orthopedic management. This case highlights the importance of maintaining a high index of suspicion for hyperfibrinolysis in patients with hemophilia following trauma, as early diagnosis and targeted intervention are critical for optimal outcomes. Our case report underscores the need for individualized, multidisciplinary management in this unique population.