Genome architecture drives antifungal resistance in Candida auris
Antifungal resistance often results from mutations in drug target genes. However, Narayanan et al. show that segmental duplication and supernumerary chromosomes also contribute to resistance in the emerging fungal pathogen Candida auris. The work expands the genetic basis of antifungal resistance and redefines the mutation-centric paradigm.
Authors
- Nityendra Shukla (ORCID: https://orcid.org/0000-0001-6664-5459)
- Anuradha Chowdhary (ORCID: https://orcid.org/0000-0002-2028-7462)
- Neeraj Chauhan (ORCID: https://orcid.org/0000-0002-9252-9897)
Institutions
- University of Delhi (IN)
- Hackensack Meridian Health (US)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-10-09
- DOI
- https://doi.org/10.1038/s41467-026-78280-8
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00