Novel Compounds as TREM2 Agonists for Treating Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, Nasu-Hakola Disease, and Stroke
Abstract Provided herein are novel compounds as TREM2 agonists, pharmaceutical compositions, use of such compounds in treating Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Nasu-Hakola disease and stroke, and processes for preparing such compounds.
Authors
- Ram W. Sabnis (ORCID: https://orcid.org/0000-0001-7289-0581)
- Anika R. Sabnis (ORCID: https://orcid.org/0009-0008-9940-6583)
Institutions
- Mayo Clinic (US)
Publication Details
- Journal
- ACS Medicinal Chemistry Letters
- Published
- 2026-10-09
- DOI
- https://doi.org/10.1021/acsmedchemlett.6c00510
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00