A candidate mitochondrial genetic-code reassignment in Pneumocystis jirovecii: a public-data research summary

Comparisons of public mitochondrial records raise a genetic-code hypothesis in Pneumocystis jirovecii: UGA may specify arginine at sites currently annotated as tryptophan. The signal recurs across the examined records, but accession counts overstate the number of independent biological samples because the set includes a reference record and its source sequence. A public RNA dataset bears on an alternative explanation without establishing protein translation. No direct protein-level evidence or demonstrated decoding mechanism is available in the analysis. This note documents a candidate reassignment, not a confirmed genetic code or a clinical finding.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-10-08
DOI
https://doi.org/10.5281/zenodo.23233893
Primary Topic
RNA and protein synthesis mechanisms
Type
article
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article

A candidate mitochondrial genetic-code reassignment in Pneumocystis jirovecii: a public-data research summary

Byungwoong Yoo
Zenodo (CERN European Organization for Nuclear Research)
RNA and protein synthesis mechanisms
article

A candidate mitochondrial genetic-code reassignment in Pneumocystis jirovecii: a public-data research summary

Byungwoong Yoo
article en

Abstract

Comparisons of public mitochondrial records raise a genetic-code hypothesis in Pneumocystis jirovecii: UGA may specify arginine at sites currently annotated as tryptophan. The signal recurs across the examined records, but accession counts overstate the number of independent biological samples because the set includes a reference record and its source sequence. A public RNA dataset bears on an alternative explanation without establishing protein translation. No direct protein-level evidence or demonstrated decoding mechanism is available in the analysis. This note documents a candidate reassignment, not a confirmed genetic code or a clinical finding.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 22%
RNA and protein synthesis mechanisms
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