Hydration-Triggered Dry Polysaccharide Coatings for pH-Sequential Delivery of Magnesium Bisglycinate: A Protocol and Simulation Study

Protocol and simulation study. No laboratory material was manufactured and no instrument generated the numerical results. All numerical values, uncertainty estimates, statistical outputs, and unit-level observations in this manuscript are synthetic and are presented solely for method development, plausibility assessment, and study planning. This record must not be cited as measured product performance or as an empirical experiment. The study defines a reproducible framework for evaluating dry starch-pectin-pullulan coatings around magnesium bisglycinate particles under sequential pH 1.2 and pH 6.8 dissolution conditions. Four coating levels are considered, together with prospective acceptance criteria for gastric retention, post-switch release, surface coverage, analytical mass balance, and variability. The simulated profiles indicate coating-level-dependent release retardation, but none meets all proposed criteria. The manuscript therefore supports a narrowly bounded conclusion: the proposed hydrophilic blend is a candidate release-rate modifier and not a validated enteric or site-specific delivery system. Traceable laboratory data are required before any empirical, bioavailability, or product-performance claim can be made.