Autoimmune and inflammatory diseases associated with T-cell clonal expansion
Autoimmune and inflammatory diseases (AID) result from a breakdown of immune tolerance, often driven by T-cell dysregulation and sometimes associated with clonal T-cell expansion. While T-cell large granular lymphocyte leukemia (LGL-L) is a well-defined clonal disorder commonly associated with AID, the clinical relevance of T-cell clones of uncertain significance (T-CUS) remains unclear. We conducted a retrospective multicenter study across six French centers, including patients with persistent circulating clonal T cells associated with AID, confirmed by T-cell receptor gene rearrangement. T-cell clones ≥ 0.5 × 10⁹/L, or low-count clones (.
Authors
- Jean-Maxime Piot
- Yannick Le Bris (ORCID: https://orcid.org/0000-0002-0095-6999)
- F. Rétornaz (ORCID: https://orcid.org/0000-0002-4997-1487)
- Nathalie Denizon
- Cécile Guenot
- Lionel Galicier (ORCID: https://orcid.org/0000-0002-0360-7620)
- N. Schleinitz (ORCID: https://orcid.org/0000-0001-9449-3392)
- Guillemette Fouquet (ORCID: https://orcid.org/0000-0002-3751-393X)
- Jérémie Dion (ORCID: https://orcid.org/0000-0002-1135-0351)
- Matthieu Groh (ORCID: https://orcid.org/0000-0003-0810-136X)
- Marinela Sisiroi
- Alexis Régent (ORCID: https://orcid.org/0000-0002-8136-2454)
- Bénédicte Deau (ORCID: https://orcid.org/0000-0002-7468-5466)
- Carole Lacout (ORCID: https://orcid.org/0000-0003-2875-6048)
- Agathe Boussaroque (ORCID: https://orcid.org/0000-0002-6238-9504)
- Nicolas Chapuis (ORCID: https://orcid.org/0000-0003-0601-3948)
- Christian Lavigne (ORCID: https://orcid.org/0000-0002-2538-0076)
- Paul Legendre (ORCID: https://orcid.org/0000-0003-2787-5491)
- Nicolas Blin (ORCID: https://orcid.org/0000-0002-0432-9343)
- Cédric Pastoret (ORCID: https://orcid.org/0000-0002-5675-3154)
- Emmanuel Ribeiro
- Benjamin Terrier (ORCID: https://orcid.org/0000-0001-6612-7336)
- T. Lamy (ORCID: https://orcid.org/0000-0002-0188-7841)
- Mickael Ebbo
- Aline Moignet
- Chloé Dol
- Camille Frelicot
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Université Rennes 2 (FR)
- Assistance Publique Hôpitaux de Marseille (FR)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen (FR)
- Hôpital Saint-André (FR)
- Centre Hospitalier du Mans (FR)
- Centre Hospitalier Universitaire de Rennes (FR)
- Hôpital de la Timone (FR)
- Institut des Maladies Génétiques Imagine (FR)
- Université d'Angers (FR)
- Université de Rennes (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Haematologica
- Published
- 2026-10-08
- DOI
- https://doi.org/10.3324/haematol.2026.301123
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00