A candidate identity for UNK-g in the Trypanosoma brucei mitoribosome: a public-data research summary

Public structural records contain a mitochondrial ribosome assembly component whose gene identity remains unassigned in the records examined. A computational comparison nominates Q38DP6 (Tb927.9.11350) as a candidate for this component, UNK-g, in Trypanosoma brucei. Structural resemblance, compatibility with the deposited density, and published proteomic observations support the nomination, but they do not establish the assignment. Several structural assessments reuse the same observations, and a custom sequence-assessment statistic is not calibrated sufficiently to provide a confirmation probability. This note records the candidate and the limits of the evidence. It does not establish a molecular function, direct interaction, or therapeutic application.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-10-08
DOI
https://doi.org/10.5281/zenodo.23233833
Primary Topic
RNA and protein synthesis mechanisms
Type
article
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article

A candidate identity for UNK-g in the Trypanosoma brucei mitoribosome: a public-data research summary

Byungwoong Yoo
Zenodo (CERN European Organization for Nuclear Research)
RNA and protein synthesis mechanisms
article

A candidate identity for UNK-g in the Trypanosoma brucei mitoribosome: a public-data research summary

Byungwoong Yoo
article en

Abstract

Public structural records contain a mitochondrial ribosome assembly component whose gene identity remains unassigned in the records examined. A computational comparison nominates Q38DP6 (Tb927.9.11350) as a candidate for this component, UNK-g, in Trypanosoma brucei. Structural resemblance, compatibility with the deposited density, and published proteomic observations support the nomination, but they do not establish the assignment. Several structural assessments reuse the same observations, and a custom sequence-assessment statistic is not calibrated sufficiently to provide a confirmation probability. This note records the candidate and the limits of the evidence. It does not establish a molecular function, direct interaction, or therapeutic application.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 23%
RNA and protein synthesis mechanisms
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