Reusable R analysis modules accompanying "Multi-scale integration identifies an ox-LDL-autophagy-inflammasome framework linking osteoporosis and neurodegeneration"

This software package accompanies the manuscript Multi-scale integration identifies an ox-LDL-autophagy-inflammasome framework linking osteoporosis and neurodegeneration. The package contains six reusable R modules for data input and validation, statistical and complex-survey analysis, Mendelian randomization from already harmonised instruments, ordinary differential equation analysis, transcriptomic analysis, and plotting. Functions operate on caller-supplied data, column mappings, groups, gene sets, model equations, and parameters. The archive includes a README, a dependency version inventory, and an MIT license.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-10-08
DOI
https://doi.org/10.5281/zenodo.23239961
Primary Topic
Atherosclerosis and Cardiovascular Diseases
Type
article
Field-Weighted Citation Impact
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article

Reusable R analysis modules accompanying "Multi-scale integration identifies an ox-LDL-autophagy-inflammasome framework linking osteoporosis and neurodegeneration"

Liang Shi, Lei Huang, Haojun Shi, Min Chen
Zenodo (CERN European Organization for Nuclear Research)
Atherosclerosis and Cardiovascular Diseases
article

Reusable R analysis modules accompanying "Multi-scale integration identifies an ox-LDL-autophagy-inflammasome framework linking osteoporosis and neurodegeneration"

Liang Shi, Lei Huang, Haojun Shi, Min Chen
article en

Abstract

This software package accompanies the manuscript Multi-scale integration identifies an ox-LDL-autophagy-inflammasome framework linking osteoporosis and neurodegeneration. The package contains six reusable R modules for data input and validation, statistical and complex-survey analysis, Mendelian randomization from already harmonised instruments, ordinary differential equation analysis, transcriptomic analysis, and plotting. Functions operate on caller-supplied data, column mappings, groups, gene sets, model equations, and parameters. The archive includes a README, a dependency version inventory, and an MIT license.

Zenodo (CERN European Organization for Nuclear Research)
Macau University of Science and Technology (MO), University of Massachusetts Chan Medical School (US), Shandong First Medical University (CN)
Openalex Percentile: Top 20%
Atherosclerosis and Cardiovascular Diseases
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