Evidence‐Based Clinical Practice Guidelines for the Management of Pediatric Febrile Neutropenia: Resource‐Sensitive Recommendations for the Asian Continent
ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes. A multidisciplinary panel, including patient advocates from 10 countries developed a clinical practice guideline (CPG) for FN using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology. The final CPG contains 25 recommendations addressing regional priorities in diagnosis, risk stratification, and management. This CPG creates a regional standard to be tailored and studied in local context.
Authors
- Sheena Teresa Mukkada (ORCID: https://orcid.org/0000-0001-5435-3707)
- Shweta Bansal (ORCID: https://orcid.org/0000-0002-1740-5421)
- Tea Reljic (ORCID: https://orcid.org/0000-0003-2029-6753)
- Catherine G. Lam (ORCID: https://orcid.org/0000-0003-1363-5331)
- Sergio Licona (ORCID: https://orcid.org/0009-0003-5618-5913)
- Nawachai Lertvivatpong (ORCID: https://orcid.org/0009-0006-4359-0073)
- Su Yadana (ORCID: https://orcid.org/0000-0003-0447-2083)
- Hamidah Alias (ORCID: https://orcid.org/0000-0003-3952-5368)
- Sally Jane Velasco-Aro
- Bambang Ardianto (ORCID: https://orcid.org/0000-0002-2267-2137)
- Krishna Sagar Sharma (ORCID: https://orcid.org/0000-0002-2493-6255)
- Sally Jane Blair (ORCID: https://orcid.org/0009-0008-4423-725X)
- Bun Sereyleak
- Eggi Arguni (ORCID: https://orcid.org/0000-0001-7462-7904)
- Ambuj Kumar (ORCID: https://orcid.org/0000-0003-1260-6694)
- Thị Tâm Đặng
- Ratha Mlis (ORCID: https://orcid.org/0009-0004-0555-291X)
- Sri Andini Handayani (ORCID: https://orcid.org/0000-0003-2908-1329)
- Vivian Moreno Berrio
- Miriam Kimpo
- Samanmalee Gunasekara
- Allyne Montecillo‐Aguelo
- Joliza Patricia Cañeba (ORCID: https://orcid.org/0009-0003-5744-9810)
- Anna Lisa Ong‐Lim
- Ha Thu Pham
- Ana Loseo
- Farrah Amaranto
- Maria Beatriz Gepte
- Maria Stella Aquino‐Calingasan
- Nguyen Hoai Anh
Institutions
- St. Jude Children's Research Hospital (US)
- Universitas Gadjah Mada (ID)
- University of South Florida (US)
- Lung Center of the Philippines (PH)
- Hospital Kuala Lumpur (MY)
- Sir H.N. Reliance Foundation Hospital and Research Centre (IN)
- Angkor Hospital for Children (KH)
- Calmette Hospital (KH)
- Philippine General Hospital (PH)
- Philippine Medical Association (PH)
- University of Southern Philippines Foundation (PH)
- Phramongkutklao Hospital (TH)
- B.P. Koirala Memorial Cancer Hospital (NP)
- Hue Central Hospital (VN)
- National Cancer Institute of Sri Lanka (LK)
- Vietnam National Children's Hospital (VN)
- National University Hospital (SG)
- Philippine Heart Center (PH)
- University of the Philippines Manila (PH)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2026-10-07
- DOI
- https://doi.org/10.1002/1545-5017.70743
- Primary Topic
- Neutropenia and Cancer Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00