Multiple Brownish Patches on the Trunk in a Patient With Neck Masses

A patient with a history of lung adenocarcinoma had violaceous-to-brown cutaneous patches and plaques. Computed tomography showed splenomegaly and multicentric lymphadenopathy, and laboratory testing showed an elevated erythrocyte sedimentation rate and levels of IgG, IgG4, IgA, and interleukin 6. What is the diagnosis and what would you do next?

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Publication Details

Journal
JAMA
Published
2026-10-07
DOI
https://doi.org/10.1001/jama.2026.13891
Primary Topic
IgG4-Related and Inflammatory Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

Multiple Brownish Patches on the Trunk in a Patient With Neck Masses

Yng Sun, Yi-Shan Teng
JAMA
IgG4-Related and Inflammatory Diseases
article

Multiple Brownish Patches on the Trunk in a Patient With Neck Masses

Yng Sun, Yi-Shan Teng
article en

Abstract

A patient with a history of lung adenocarcinoma had violaceous-to-brown cutaneous patches and plaques. Computed tomography showed splenomegaly and multicentric lymphadenopathy, and laboratory testing showed an elevated erythrocyte sedimentation rate and levels of IgG, IgG4, IgA, and interleukin 6. What is the diagnosis and what would you do next?

JAMA
Kaohsiung Medical University (TW), Kaohsiung Medical University Chung-Ho Memorial Hospital (TW), Aesthetic Surgery Center (US)
Openalex Percentile: Top 11%
IgG4-Related and Inflammatory Diseases
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