New Polyurethane/ O ‐Carboxymethyl Chitosan Composite Product for Next‐Generation Wound Dressings

ABSTRACT Complex wounds represent a significant clinical challenge, requiring advanced wound dressings capable of combining mechanical stability, moisture control, and bioactivity. In this study, hybrid polyurethane (PU) and O ‐carboxymethyl chitosan (OCMCh) composites were developed through surface chemical modification to enhance multifunctional performance. The interaction between PU and OCMCh was carefully investigated, indicating the formation of covalent amide bonds associated with protonation and deprotonation mechanisms. The composites were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), optical microscopy (OM), scanning electron microscopy (SEM), contact angle measurements to evaluate surface wettability, and mechanical testing to assess their mechanical performance. In addition, their antimicrobial activity and cytocompatibility were evaluated to determine their biological performance and suitability for wound dressing applications. The incorporation of OCMCh significantly increased hydrophilicity and water absorption capacity under optimized conditions (24 h, 40°C, pH ~7.4), maintaining thermal stability adequate for biomedical profile. Morphological analysis revealed a homogeneous and porous structure, which is favorable for exudate management and cell interaction. Compared to conventional commercial dressings such as Tegaderm and Allevyn, the composites exhibited improved wettability and enhanced fluid absorption capacity, indicating superior performance in maintaining a moist wound environment. Furthermore, the combination of synthetic and natural polymers contributes to improved functional properties and expands the potential applications of these materials in biomedical fields. These results suggest that PU/OCMCh composites are promising candidates for next‐generation wound dressings.