The origins of rare glycosylphosphatidylinositol-deficient cells in normal and immune-mediated hematopoiesis
Single-cell-resolution PIGA sequencing showed that rare glycosylphosphatidylinositol-deficient cells in healthy individuals are polyclonal, comprising long-lived hematopoietic stem/progenitor-derived clones and nonpersistent populations. Those in acquired aplastic anemia reflect the selective expansion of multipotent PIGA-mutant stem/progenitor cells across myeloid and lymphoid lineages.
Authors
- Tatsuya Imi (ORCID: https://orcid.org/0000-0002-7674-7368)
- Kazuyoshi Hosomichi (ORCID: https://orcid.org/0000-0003-2712-1825)
- Kohei Thi Hosokawa (ORCID: https://orcid.org/0000-0002-3423-1523)
- Shinji Nakao (ORCID: https://orcid.org/0000-0002-9674-624X)
- Yoshitaka Zaimoku (ORCID: https://orcid.org/0000-0002-4108-5245)
- Eriko Morishita (ORCID: https://orcid.org/0000-0001-9116-3363)
- Seishi Ogawa (ORCID: https://orcid.org/0000-0002-7778-5374)
- Hirohito Yamazaki (ORCID: https://orcid.org/0000-0003-3018-2098)
- Hiroki Mizumaki (ORCID: https://orcid.org/0000-0002-9933-4638)
- Miku Kobayashi
- Yui Kano
- Toshihiro Miyamoto
- Yasuhito Nannya
- Dung Cao Tran (ORCID: https://orcid.org/0009-0003-4272-6862)
Institutions
- Kanazawa University (JP)
- Tokyo University of Pharmacy and Life Sciences (JP)
- Kanazawa Medical University (JP)
- Kyoto University (JP)
- Kanazawa University Hospital (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Blood
- Published
- 2026-10-07
- DOI
- https://doi.org/10.1182/blood.2026033685
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00