Periodontitis GWAS Reveal Immune‐Biased Heritability Without Gingival Cell‐Type Resolution
Three methodologically distinct analyses partition periodontitis common-variant heritability across 27 gingival cell types. They agree on an immune-over-stromal direction but nominate three different top cell types, and a low-power analysis inverts the fibroblast signal; the current periodontitis GWAS therefore cannot resolve heritability to a single gingival cell type.
Authors
- Guoli Yang (ORCID: https://orcid.org/0000-0002-1780-8757)
- Chengze Wang (ORCID: https://orcid.org/0000-0003-2349-6427)
- Wenyue An
- Ying Wang
- Mengna Lin
Institutions
- Zhejiang University Medical College Affiliated Stomatological Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Periodontal Research
- Published
- 2026-10-07
- DOI
- https://doi.org/10.1111/jre.70179
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00