Large language models for digital mental health: an HCI-centered scoping review

Large language models (LLMs) are rapidly reshaping digital mental health, yet how these systems are designed, used, and evaluated remains poorly characterized. We conducted an HCI-centered scoping review of 84 studies examining mental health tasks, stakeholders, interaction paradigms, foundation models, evaluation methods, and outcome measurement. Counseling and support and self-help and well-being accounted for 73.8% of studies, while clinician support and crisis and risk support remained uncommon. Mixed-methods user studies predominated (42.9%), with only three randomized controlled trials and eight studies classified as longitudinal or field evaluations. Technical and response performance was assessed in 81.0% of studies, compared with 29.8% assessing mental health symptoms and clinical outcomes and 7.1% including longitudinal follow-up. Outcome profiles differed across intended tasks. Building on these findings and established evaluation guidance, we propose a task-oriented framework aligning evaluation domains, measurement approaches, and assessment timing with intended use.

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Publication Details

Journal
npj Digital Medicine
Published
2026-10-07
DOI
https://doi.org/10.1038/s41746-026-03317-7
Primary Topic
Digital Mental Health Interventions
Type
article
Field-Weighted Citation Impact
0.00
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article

Large language models for digital mental health: an HCI-centered scoping review

Yu Hou, Kai Yu, Zaifu Zhan, Min Zeng et al.
npj Digital Medicine
Digital Mental Health Interventions
article

Large language models for digital mental health: an HCI-centered scoping review

Yu Hou, Kai Yu, Zaifu Zhan, Min Zeng, Chao Zeng, Shuang Zhou, Rui Zhang, Mingquan Lin, Duzhen Zhang
article en

Abstract

Large language models (LLMs) are rapidly reshaping digital mental health, yet how these systems are designed, used, and evaluated remains poorly characterized. We conducted an HCI-centered scoping review of 84 studies examining mental health tasks, stakeholders, interaction paradigms, foundation models, evaluation methods, and outcome measurement. Counseling and support and self-help and well-being accounted for 73.8% of studies, while clinician support and crisis and risk support remained uncommon. Mixed-methods user studies predominated (42.9%), with only three randomized controlled trials and eight studies classified as longitudinal or field evaluations. Technical and response performance was assessed in 81.0% of studies, compared with 29.8% assessing mental health symptoms and clinical outcomes and 7.1% including longitudinal follow-up. Outcome profiles differed across intended tasks. Building on these findings and established evaluation guidance, we propose a task-oriented framework aligning evaluation domains, measurement approaches, and assessment timing with intended use.

npj Digital Medicine
University of Minnesota (US), Mohamed bin Zayed University of Artificial Intelligence (AE)
Openalex Percentile: Top 8%
Digital Mental Health Interventions
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Large language models for digital mental health: an HCI-centered scoping review — Yu Hou, Kai Yu, et al. · npj Digital Medicine (2026) | TGRS Research Map | TGRS