Instrumental Evaluation of Skin Structural Parameters After 56 Days of Use of a Home-Use LED Photobiomodulation Device

Light-emitting diode (LED) photobiomodulation has emerged as a non-invasive approach for skin quality improvement and reduction in visible aging signs. This study evaluated the efficacy and tolerability of a combined skincare regimen consisting of a home-use silicone LED facial mask emitting red light used together with a cosmetic serum for skin rejuvenation. An open, single-centre clinical study without a control group was conducted in 20 healthy female volunteers aged 40–55 years presenting visible facial wrinkles and skin imperfections. Participants used the LED mask twice daily for 10 min over 56 days, each session being followed by application of a standardized cosmetic serum, so that the LED device and the serum were evaluated as a single combined regimen. Skin evaluations were performed at baseline (D0), after 28 days (D28), and after 56 days (D56) using three-dimensional skin topography (AEVA-HE), high-frequency ultrasound imaging (Ultrascan® UC22), biomechanical measurements (Cutometer® dual MPA 580), and pigmentation analysis (Mexameter® MX18). In the exploratory analysis, a statistically significant improvement in the Cutometer firmness parameter (F4) was observed at D56 compared with baseline (p = 0.03). Changes in elasticity, pigmentation, wrinkle-related topographic measurements and dermal thickness did not reach statistical significance and are reported only as non-significant numerical trends. The treatment was well tolerated, with no significant skin reactions observed. These preliminary findings suggest that a combined regimen incorporating home-use LED photobiomodulation and a cosmetic serum may be associated with an improvement in skin firmness. Because the study was uncontrolled and the LED device was used together with a serum, the observed changes cannot be attributed to photobiomodulation alone and should be interpreted as preliminary.