Fungal Infectious Necrotizing Scleritis Following Vegetative Ocular Trauma

Infectious necrotizing scleritis (INS) is a rare, vision-threatening condition that often resembles immune-mediated scleritis, leading to delayed diagnosis and inappropriate corticosteroid use. We report a 45-year-old diabetic farmer who developed severe pain, redness, purulent discharge, and progressive visual loss in the right eye 3 weeks after vegetative ocular trauma. Initial treatment with topical corticosteroids failed to improve symptoms. Best-corrected visual acuity was 3/60, and slit-lamp examination revealed localized scleral necrosis with conjunctival ulceration and purulent exudate. Autoimmune investigations were negative. Surgical debridement with microbiological evaluation demonstrated septate fungal hyphae on potassium hydroxide mount, and culture confirmed Aspergillus species. Intensive topical and systemic antifungal therapy with repeated debridement achieved infection control and preserved globe integrity. Corticosteroids were introduced only after microbiological resolution. Residual scleral thinning was noted at follow-up. Early microbiological diagnosis and combined medical-surgical management are essential for favorable outcomes in fungal INS.

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Publication Details

Journal
Infectious Diseases in Clinical Practice
Published
2026-10-06
DOI
https://doi.org/10.1097/ipc.0000000000001691
Primary Topic
Ocular Infections and Treatments
Type
article
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article

Fungal Infectious Necrotizing Scleritis Following Vegetative Ocular Trauma

Vidhya Verma, Samendra Karkhur, Saroj Gupta, Priti Singh et al.
Infectious Diseases in Clinical Practice
Ocular Infections and Treatments
article

Fungal Infectious Necrotizing Scleritis Following Vegetative Ocular Trauma

Vidhya Verma, Samendra Karkhur, Saroj Gupta, Priti Singh, Akansha Verma
article en

Abstract

Infectious necrotizing scleritis (INS) is a rare, vision-threatening condition that often resembles immune-mediated scleritis, leading to delayed diagnosis and inappropriate corticosteroid use. We report a 45-year-old diabetic farmer who developed severe pain, redness, purulent discharge, and progressive visual loss in the right eye 3 weeks after vegetative ocular trauma. Initial treatment with topical corticosteroids failed to improve symptoms. Best-corrected visual acuity was 3/60, and slit-lamp examination revealed localized scleral necrosis with conjunctival ulceration and purulent exudate. Autoimmune investigations were negative. Surgical debridement with microbiological evaluation demonstrated septate fungal hyphae on potassium hydroxide mount, and culture confirmed Aspergillus species. Intensive topical and systemic antifungal therapy with repeated debridement achieved infection control and preserved globe integrity. Corticosteroids were introduced only after microbiological resolution. Residual scleral thinning was noted at follow-up. Early microbiological diagnosis and combined medical-surgical management are essential for favorable outcomes in fungal INS.

Infectious Diseases in Clinical PracticeVol. 34(6)
Openalex Percentile: Top 8%
Ocular Infections and Treatments
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Fungal Infectious Necrotizing Scleritis Following Vegetative Ocular Trauma — Vidhya Verma, Samendra Karkhur, et al. · Infectious Diseases in Clinical Practice (2026) | TGRS Research Map | TGRS