The Second Renaissance: Why System and Complexity Science Is the "Metascience of Metasciences"

Modern science was established upon the "vertical specialization" of Cartesian and Newtonian reductionism, achieving immense local success in micro-isolated slices. However, when confronted with strongly coupled Open Complex Giant Systems (OCGS), reductionism universally traps itself in a systemic dissipation mire of micro-state combinatorial explosion and macro work "vector cancellation" (∑_{i=1}^N v_i → 0). Starting from epistemological first principles, this paper establishes the academic status of System and Complexity Science as a "Metascience of Metasciences": humans are physically incapable of directly accessing raw physical reality; all scientific research and engineering practice essentially operate through an observer-constructed "Ought-to-be System" to observe, simulate, and govern the real world. The Ought-to-be System is itself a complex system; lacking holistic governance, non-orthogonal conflicts inside the model trigger cognitive vector cancellation, causing macro simulation and micro governance to fail completely. Taking an 18-year continuous operational field of large-scale high-frequency discrete entity work networks—achieving a Human-Out-Of-The-Loop (HOOTL) autonomous decision rate > 95%—as its genetic origin, this paper demonstrates that the core physical fact lies in sustaining high-frequency closed loops of "planning—execution—feedback" and autonomous decision-making. This proves the closed-loop computability of Open Complex Giant Systems, enabling systems to maintain long-term "generation, survival, and evolution" (Closed-Loop Persistence). On this foundation, this paper establishes a strict decoupling between qualitative deduction and quantitative proof: 1. Qualitative Dimension: Grounded in Professor Longbing Cao's first principle of Non-Independent and Identically Distributed (Non-IID) dynamics, the paper develops the "Qualitative Eight Treatises" (Teleology, Ontology, Schematics, Capability, Mechanism, Path, Dynamics, Evolution) as a causal deduction chain from micro-coupling to second-order constitutional amendments. While affirming the local value of current technical paradigms, the paper delineates the theoretical boundaries and cybernetic limitations of Multi-AI Agent free collaboration, classical solvers and statistical machine learning under IID assumptions, traditional IT linear division of labor, multi-head joint committees, decentralized free gaming, open-loop visualization dashboards, unauthorized multi-head tug-of-war, and fully unattended AI systems. Concurrently, it establishes a 1:1 isomorphic mapping between the Eight Treatises and Qian Xuesen's OCGS theory. 2. Quantitative Dimension: Introducing the "Dual-Helix Architecture"—composed of a 5D physical topological data manifold (Form) and a minimal evolution algorithm (Function)—this paper proves Causal Characteristic Line Decoupling & Polynomial Computability (Theorem 7.2) under boundary conditions. Based on algorithmic orthogonal pruning, it establishes the tripartite physical equivalence: "Traversability ≡ Zero Cancellation ≡ In-Boundary Absolute Optimality" (Proposition 7.3, ∃! S*_k ∈ Ω_feasible). Coupled with the meta-cognitive constitutional amendment operator Φ, it unifies a three-tier spatiotemporal closed loop of survival and evolution (Theorem 8.1). Core Theoretical Breakthrough: The paper supplies formal mathematical proofs for Qian Xuesen's three core OCGS principles—Metasynthetic Department, Hall of Workshop for Metasynthetic Engineering (HWME/HWDS), and Human-Machine Combination / Human-Led—in entity discrete manufacturing value networks featuring causal DAG structures, bypassing Wolfram computational irreducibility hurdles under restricted structures. Empirical Validation: 18 years of 100-billion-level industrial field practice, ablation comparisons, and third-party audited data verify that constructing a physical "Plan-Execute-Feedback" (PEF) self-healing closed loop is the effective path for eliminating internal vector cancellation and elevating ROIC. Key results include OTD 98.4%, inventory turnover 24.6 turns/year, over 3.5 billion RMB in Net Working Capital released, and line stoppage frequency reduced from >22 times/month to <2 times/month. Finally, this paper demonstrates the cross-domain entity neutrality of the Dual-Helix Architecture and provides a rigorous Popperian Falsifiability Matrix. Continuing the scientific tradition of Qian Xuesen and Academician Lei Guo, this work supplies a dual foundation of qualitative deduction and quantitative computability for Metasynthetic Engineering in Open Complex Giant Systems.