Ligand Accelerated Palladium-Catalyzed C–H Arylation of Electron-Deficient Polyfluoroarenes with Aryl Bromides
Abstract A ligand accelerated highly efficient palladium-catalyzed C–H arylation of electron-deficient polyfluoroarenes with aryl and heteroaryl bromides has been developed. The reaction proceeds efficiently under mild conditions with low catalyst loading (0.25 mol % Pd) and ligand loading (0.275 mol %), affording a broad range of fluorinated biaryl products in good to excellent yields. The methodology exhibits a wide substrate scope and good functional group tolerance. Its synthetic utility is demonstrated through the concise synthesis of several industrially relevant molecules, highlighting the practicality, efficiency, and scalability of the catalytic system.
Authors
- Venkatarathnam Nasipireddy
- Chetan Joshi (ORCID: https://orcid.org/0000-0003-0071-4313)
- Leleti Rajender Reddy (ORCID: https://orcid.org/0000-0001-9182-2277)
- Venkata Surya Kumar Choutipalli (ORCID: https://orcid.org/0000-0003-3847-2620)
- Chris H. Senanayake (ORCID: https://orcid.org/0009-0009-3170-0687)
- Mohammed Sharique (ORCID: https://orcid.org/0000-0002-4528-4807)
- Lalitha Gummidi (ORCID: https://orcid.org/0000-0002-1357-2468)
- Omkar Revu
- Lalith P. Samankumara
- Anji Chen (ORCID: https://orcid.org/0000-0002-8943-9663)
- Rajasekar Reddy Annapureddy (ORCID: https://orcid.org/0000-0001-5855-4688)
- G. Sudhakar Reddy (ORCID: https://orcid.org/0000-0001-8301-2207)
- Madhusudhan Reddy Gadi (ORCID: https://orcid.org/0000-0003-3668-4646)
- Praveen Kumar Gajula (ORCID: https://orcid.org/0009-0008-5051-4612)
- Jonathan M. Bietsch
- Shada Arun Dixith Reddy (ORCID: https://orcid.org/0000-0002-0672-7441)
- Badrinath N. Kakde (ORCID: https://orcid.org/0000-0003-0018-2855)
- Gopal Sirasani
- Sailu Munnuri (ORCID: https://orcid.org/0000-0001-5675-6032)
- V. Subramanian (ORCID: https://orcid.org/0000-0003-2463-545X)
- Srinivasarao Tenneti (ORCID: https://orcid.org/0000-0002-6687-8348)
- Santhosh Reddy Naini (ORCID: https://orcid.org/0000-0001-7825-5810)
- Bo Qu (ORCID: https://orcid.org/0000-0001-7347-0108)
- Sameera Siyabalapitiya Arachchige (ORCID: https://orcid.org/0000-0003-4376-7415)
- Nageswara Rao Kalikinidi (ORCID: https://orcid.org/0000-0002-5378-9207)
- Shanika M. P. Gamage
- Srinivasrao Ganipisetti
- Sridhar Regati
- Rahul Dilip Shingare
- Annada Maity
- Virendra Tiwari
- Jonathan Gordon
Publication Details
- Journal
- Organic Letters
- Published
- 2026-10-07
- DOI
- https://doi.org/10.1021/acs.orglett.6c03763
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00