MiKid-QA: construction and performance evaluation of a paediatric myopia education question-answering model

Background The surging prevalence of paediatric myopia has overwhelmed clinical education services. While general-purpose large language models (LLMs) are increasingly used for medical information, they often lack the domain-specific precision required for specialised care. This study aimed to develop and evaluate Myopia in Kids Question-Answering (MiKid-QA), a paediatric myopia education question-answering model fine-tuned to support standardised patient education. Methods We conducted a cross-sectional evaluation study. MiKid-QA was developed by fine-tuning the Qwen2.5-32B model using low-rank adaptation (LoRA) on curated professional datasets (2015–2025), including textbooks and expert consensus. Performance was assessed against DeepSeek and GPT-4 through a multicentre, single-blind expert evaluation of 25 standardised clinical scenarios. A panel of specialists rated responses across five dimensions (correctness, completeness, readability, helpfulness and safety) using a 5-point Likert scale. Results MiKid-QA demonstrated superior automated performance compared with its base model (Bilingual Evaluation Understudy: 0.1423 vs 0.0967). In expert evaluations, MiKid-QA achieved significantly higher scores for correctness (4.43±0.63) and safety (4.38±0.59) compared with DeepSeek and GPT-4 (all p<0.001). While completeness and helpfulness were comparable (p>0.05), MiKid-QA produced more concise responses and lower reading difficulty than GPT-4 (p<0.001), suggesting a potentially favourable balance between information accuracy and patient accessibility in standardised educational scenarios. Conclusion Specialised fine-tuning on curated myopia-related datasets was associated with higher expert-rated correctness and safety in standardised myopia education scenarios. MiKid-QA may serve as an auxiliary educational tool to support patient communication in myopia care, although further external validation and prospective clinical studies are required before clinical deployment.

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Publication Details

Journal
British Journal of Ophthalmology
Published
2026-10-06
DOI
https://doi.org/10.1136/bjo-2026-329816
Primary Topic
Artificial Intelligence in Healthcare and Education
Type
article
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article

MiKid-QA: construction and performance evaluation of a paediatric myopia education question-answering model

Bei Du, 鹿大千, X. J. Zhang, Ruihua Wei et al.
British Journal of Ophthalmology
Artificial Intelligence in Healthcare and Education
article

MiKid-QA: construction and performance evaluation of a paediatric myopia education question-answering model

Bei Du, 鹿大千, X. J. Zhang, Ruihua Wei, Jingtao Yu, Jing Yang, Zixun Wang, Xueshuo Xie, Yabin Hu, Tingyu Zhang, Liqin Huang, Xu Yan, Xiaoxue Hu, Yifan Li, Jun Zhou
article en

Abstract

Background The surging prevalence of paediatric myopia has overwhelmed clinical education services. While general-purpose large language models (LLMs) are increasingly used for medical information, they often lack the domain-specific precision required for specialised care. This study aimed to develop and evaluate Myopia in Kids Question-Answering (MiKid-QA), a paediatric myopia education question-answering model fine-tuned to support standardised patient education. Methods We conducted a cross-sectional evaluation study. MiKid-QA was developed by fine-tuning the Qwen2.5-32B model using low-rank adaptation (LoRA) on curated professional datasets (2015–2025), including textbooks and expert consensus. Performance was assessed against DeepSeek and GPT-4 through a multicentre, single-blind expert evaluation of 25 standardised clinical scenarios. A panel of specialists rated responses across five dimensions (correctness, completeness, readability, helpfulness and safety) using a 5-point Likert scale. Results MiKid-QA demonstrated superior automated performance compared with its base model (Bilingual Evaluation Understudy: 0.1423 vs 0.0967). In expert evaluations, MiKid-QA achieved significantly higher scores for correctness (4.43±0.63) and safety (4.38±0.59) compared with DeepSeek and GPT-4 (all p<0.001). While completeness and helpfulness were comparable (p>0.05), MiKid-QA produced more concise responses and lower reading difficulty than GPT-4 (p<0.001), suggesting a potentially favourable balance between information accuracy and patient accessibility in standardised educational scenarios. Conclusion Specialised fine-tuning on curated myopia-related datasets was associated with higher expert-rated correctness and safety in standardised myopia education scenarios. MiKid-QA may serve as an auxiliary educational tool to support patient communication in myopia care, although further external validation and prospective clinical studies are required before clinical deployment.

British Journal of Ophthalmology
Beijing Tongren Hospital (CN), Hong Kong Polytechnic University (HK), Sun Yat-sen University (CN), Capital Medical University (CN), Nankai University (CN), Shanghai Ninth People's Hospital (CN), Han Dan City Eye Hospital - The Third Hospital of Handan (CN), Wuhan Children's Hospital (CN), Tianjin Medical University Eye Hospital (CN), State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Tianjin Medical University (CN)
Openalex Percentile: Top 19%
Artificial Intelligence in Healthcare and Education
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