Osteosarcoma of the Jaws in Latin America: A Retrospective Multicenter Series of 119 Cases

OBJECTIVE: Epidemiological and survival data on osteosarcoma of the jaws (OSJ) in Latin America remain scarce. We characterized the clinicopathological, radiographic, treatment-related, and survival features of OSJ in Latin America. METHODS: This multicenter case series involved 22 institutions from Brazil, Chile, Argentina, Colombia, Venezuela, Uruguay, and Mexico. Demographic, clinical, radiographic, histopathological, treatment, and survival data were analyzed using descriptive and inferential statistical methods. Survival outcomes were assessed using Kaplan-Meier analysis and Cox regression models. RESULTS: A total of 119 OSJ cases were included. The median age was 33 years, with a female predominance (58%), and the mandible was the most commonly affected site (68.9%). A mixed radiographic appearance predominated and was frequently accompanied by cortical perforation and a sunburst periosteal reaction. Histologically, the osteoblastic subtype accounted for 63.5% of cases. Surgical resection was the main treatment modality (71.2%). Increasing age (p = 0.034) and multimodal or nonsurgical management (p = 0.023) were independently associated with poorer survival. The estimated overall survival rates were 67.5% at 12 months and 37.5% at 60 months. CONCLUSION: Data corroborate previous literature and demonstrate that OSJ in Latin America predominantly affects adults and exhibits aggressive patterns. Surgical management remains central to improving survival whenever it is technically feasible.

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Journal
Oral Diseases
Published
2026-10-05
DOI
https://doi.org/10.1111/odi.70519
Primary Topic
Sarcoma Diagnosis and Treatment
Type
article
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article

Osteosarcoma of the Jaws in Latin America: A Retrospective Multicenter Series of 119 Cases

Ana Paula Neutzling Gomes, Amanda Claudino Gomes, Claudia Patricia Peña Vega, Leonardo Amaral dos Reis et al.
Oral Diseases
Sarcoma Diagnosis and Treatment
article

Osteosarcoma of the Jaws in Latin America: A Retrospective Multicenter Series of 119 Cases

Ana Paula Neutzling Gomes, Amanda Claudino Gomes, Claudia Patricia Peña Vega, Leonardo Amaral dos Reis, Karina Cordero‐Torres, Lauren Frenzel Schuch, René Panico, Federico Garola, José Alcides Almeida de Arruda, Mônica Simões Israel, Lucas Guimarães Abreu, Fabrício Tinôco Alvim de Souza, Israel Leal Cavalcante, Mariana Villarroel‐Dorrego, Ricardo Alves Mesquita, Gerardo Gilligan, Diego Antônio Costa Arantes, Victor Zanetti Drumond, Manoela Domingues Martins, Nicolás Leonardi, Warley Oliveira Silva, Cassiano Francisco Weege Nonaka, Bruno Augusto Benevenuto de Andrade, ROGERIO DE OLIVEIRA GONDAK, Pollianna Muniz Alves, Aurita Verónica Beovide Cortegoso, Natalia Fernanda Tancredi Cueto, Elismauro Francisco Mendonça, Laura Leguina, Saray Aranda‐Romo, Gerhilde Callou Sampaio, J. Gimenez, Adriana Etges, Francisco Javier Tejeda Nava, Ricardo Luiz Cavalcanti de Albuquerque Júnior, Carlos Marcelo Cerullo, Eveline Turatti, Victor Hugo Lopes de Oliveira Moreira, Ronell Eduardo Bologna‐Molina, Maria Natalia González Umpiérrez, Veronica Flück, Roberta Barroso Cavalcante, Michel Campos Ribeiro, J. Martínez Mora, Ángeles Castrillo, Kallana Mezzomo Faccin, Paula Celeghini Goulart, Carolina Louzada Menna Barreto, Giovanna Tacchi, Karen Müller Bubolz, Guilherme Gomes Souza, Rolando Morales‐Espinosa
article en

Abstract

OBJECTIVE: Epidemiological and survival data on osteosarcoma of the jaws (OSJ) in Latin America remain scarce. We characterized the clinicopathological, radiographic, treatment-related, and survival features of OSJ in Latin America. METHODS: This multicenter case series involved 22 institutions from Brazil, Chile, Argentina, Colombia, Venezuela, Uruguay, and Mexico. Demographic, clinical, radiographic, histopathological, treatment, and survival data were analyzed using descriptive and inferential statistical methods. Survival outcomes were assessed using Kaplan-Meier analysis and Cox regression models. RESULTS: A total of 119 OSJ cases were included. The median age was 33 years, with a female predominance (58%), and the mandible was the most commonly affected site (68.9%). A mixed radiographic appearance predominated and was frequently accompanied by cortical perforation and a sunburst periosteal reaction. Histologically, the osteoblastic subtype accounted for 63.5% of cases. Surgical resection was the main treatment modality (71.2%). Increasing age (p = 0.034) and multimodal or nonsurgical management (p = 0.023) were independently associated with poorer survival. The estimated overall survival rates were 67.5% at 12 months and 37.5% at 60 months. CONCLUSION: Data corroborate previous literature and demonstrate that OSJ in Latin America predominantly affects adults and exhibits aggressive patterns. Surgical management remains central to improving survival whenever it is technically feasible.

Oral Diseases
Universidade Federal de Juiz de Fora (BR), Universidade Federal de Minas Gerais (BR), Universidade Federal do Rio de Janeiro (BR), Universidad Católica de Córdoba (AR), Universidade Federal do Rio Grande do Sul (BR), Universidade Estadual da Paraíba (BR), Universidad Nacional de Córdoba (AR), Universidade Federal de Pelotas (BR), Universidad de la República de Uruguay (UY), Autonomous University of San Luis Potosí (MX), Universidade Federal de Alfenas (BR), Universidade de Fortaleza (BR), Universidad Nacional de Colombia (CO), Universidade do Estado do Rio de Janeiro (BR), Universidade Federal de Santa Catarina (BR), Hospital Universitário - Universidade Federal de Juiz de Fora (BR), Hospital Dr. Gustavo Fricke (CL), Hospital Piñero (AR), Universidade Estadual de Montes Claros (BR), Universidade Federal de Goiás (BR), Universidade de Pernambuco (BR), University of Valparaíso (CL), Central University of Venezuela (VE), Universidade Federal do Estado do Rio de Janeiro (BR), Universidad Santa María (VE)
Openalex Percentile: Top 12%
Sarcoma Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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